Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

Artemisinin, an antimalarial drug, has anticancer activity and possesses protective effects against several tissue injuries. The aim of the present study was to investigate the effects of artemisinin on doxorubicin-induced renal and testicular toxicity in rats. Doxorubicin was administered to rats a...

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Autores principales:	Tutun Hidayet, Özmen Özlem, Aktaş İbrahim, Yalçin Alper, Türk Ahmet
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	artemisinin doxorubicin kidney rat testis Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/e8ad271ad0a542aa8d616448bf1822fa
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spelling	oai:doaj.org-article:e8ad271ad0a542aa8d616448bf1822fa2021-11-17T21:27:53ZInvestigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin1820-744810.2478/acve-2019-0014https://doaj.org/article/e8ad271ad0a542aa8d616448bf1822fa2019-06-01T00:00:00Zhttps://doi.org/10.2478/acve-2019-0014https://doaj.org/toc/1820-7448Artemisinin, an antimalarial drug, has anticancer activity and possesses protective effects against several tissue injuries. The aim of the present study was to investigate the effects of artemisinin on doxorubicin-induced renal and testicular toxicity in rats. Doxorubicin was administered to rats at a single dose of 10 mg/kg body weight (b.w.) as a single intraperitoneal injection. Application of artemisinin was by using oral gavage feeding needle for 14 days at different specified doses (7 mg/kg and 35 mg/kg b.w.). At the end of the experiments, kidney and testis samples were collected and used for histopathological and immunohistochemical examinations. At histopathological examination, while hyperemia was the marked finding in kidney and testis of rats treated with doxorubicin only, no evidence of structural abnormalities showed in other groups. Immunohistochemical examination of the testes and kidneys demonstrated significantly increased expression of caspase-3, TNF-α, iNOS and NF-κB in rats treated with doxorubicin only. Artemisinin decreased the doxorubicin-induced overexpression of NF-κB, iNOS, TNFα and caspase-3 in these tissues of rats. Artemisinin can protect the kidney and testis against doxorubicin-induced nephrotoxicity and testotoxicity, probably through a decrease of caspase-3, TNF-α, iNOS and NF-κB expressions. It may be concluded that artemisinin has a potential for clinical use in the treatment of kidney and testis damage induced by doxorubicin. Further researches are required to determine the appropriate combination of artemisinin with doxorubicin.Tutun HidayetÖzmen ÖzlemAktaş İbrahimYalçin AlperTürk AhmetSciendoarticleartemisinindoxorubicinkidneyrattestisVeterinary medicineSF600-1100ENActa Veterinaria, Vol 69, Iss 2, Pp 177-191 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	artemisinin doxorubicin kidney rat testis Veterinary medicine SF600-1100
spellingShingle	artemisinin doxorubicin kidney rat testis Veterinary medicine SF600-1100 Tutun Hidayet Özmen Özlem Aktaş İbrahim Yalçin Alper Türk Ahmet Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
description	Artemisinin, an antimalarial drug, has anticancer activity and possesses protective effects against several tissue injuries. The aim of the present study was to investigate the effects of artemisinin on doxorubicin-induced renal and testicular toxicity in rats. Doxorubicin was administered to rats at a single dose of 10 mg/kg body weight (b.w.) as a single intraperitoneal injection. Application of artemisinin was by using oral gavage feeding needle for 14 days at different specified doses (7 mg/kg and 35 mg/kg b.w.). At the end of the experiments, kidney and testis samples were collected and used for histopathological and immunohistochemical examinations. At histopathological examination, while hyperemia was the marked finding in kidney and testis of rats treated with doxorubicin only, no evidence of structural abnormalities showed in other groups. Immunohistochemical examination of the testes and kidneys demonstrated significantly increased expression of caspase-3, TNF-α, iNOS and NF-κB in rats treated with doxorubicin only. Artemisinin decreased the doxorubicin-induced overexpression of NF-κB, iNOS, TNFα and caspase-3 in these tissues of rats. Artemisinin can protect the kidney and testis against doxorubicin-induced nephrotoxicity and testotoxicity, probably through a decrease of caspase-3, TNF-α, iNOS and NF-κB expressions. It may be concluded that artemisinin has a potential for clinical use in the treatment of kidney and testis damage induced by doxorubicin. Further researches are required to determine the appropriate combination of artemisinin with doxorubicin.
format	article
author	Tutun Hidayet Özmen Özlem Aktaş İbrahim Yalçin Alper Türk Ahmet
author_facet	Tutun Hidayet Özmen Özlem Aktaş İbrahim Yalçin Alper Türk Ahmet
author_sort	Tutun Hidayet
title	Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
title_short	Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
title_full	Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
title_fullStr	Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
title_full_unstemmed	Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
title_sort	investigation of the effects of artemisinin on testis and kidney injury induced by doxorubicin
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/e8ad271ad0a542aa8d616448bf1822fa
work_keys_str_mv	AT tutunhidayet investigationoftheeffectsofartemisininontestisandkidneyinjuryinducedbydoxorubicin AT ozmenozlem investigationoftheeffectsofartemisininontestisandkidneyinjuryinducedbydoxorubicin AT aktasibrahim investigationoftheeffectsofartemisininontestisandkidneyinjuryinducedbydoxorubicin AT yalcinalper investigationoftheeffectsofartemisininontestisandkidneyinjuryinducedbydoxorubicin AT turkahmet investigationoftheeffectsofartemisininontestisandkidneyinjuryinducedbydoxorubicin
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Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin

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