Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

Abstract The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological disorders. This study examines whether pure...

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Autores principales:	Kirat K. Chand, Jatin Patel, S. T. Bjorkman, Seen-Ling Sim, Stephanie M. Miller, Elliot Teo, Lara Jones, Jane Sun, Paul B. Colditz, Kiarash Khosrotehrani, Julie A. Wixey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/e8b09f839fb949199093e3762d588305
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spelling	oai:doaj.org-article:e8b09f839fb949199093e3762d5883052021-11-21T12:40:30ZCombination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn10.1038/s41536-021-00185-52057-3995https://doaj.org/article/e8b09f839fb949199093e3762d5883052021-11-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00185-5https://doaj.org/toc/2057-3995Abstract The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological disorders. This study examines whether pure foetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta are neuroprotective through modulating neuroinflammation and supporting the brain vasculature. We determined that one dose of combined MSC-ECFCs (cECFC; 106 ECFC 106 MSC) on the first day of life to the newborn FGR piglet improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation and improved adverse neuronal and white matter changes present in the FGR newborn piglet brain. These findings could not be reproduced using MSCs alone. These results demonstrate cECFC treatment exerts beneficial effects on multiple cellular components in the FGR brain and may act as a neuroprotectant.Kirat K. ChandJatin PatelS. T. BjorkmanSeen-Ling SimStephanie M. MillerElliot TeoLara JonesJane SunPaul B. ColditzKiarash KhosrotehraniJulie A. WixeyNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Kirat K. Chand Jatin Patel S. T. Bjorkman Seen-Ling Sim Stephanie M. Miller Elliot Teo Lara Jones Jane Sun Paul B. Colditz Kiarash Khosrotehrani Julie A. Wixey Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
description	Abstract The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological disorders. This study examines whether pure foetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta are neuroprotective through modulating neuroinflammation and supporting the brain vasculature. We determined that one dose of combined MSC-ECFCs (cECFC; 106 ECFC 106 MSC) on the first day of life to the newborn FGR piglet improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation and improved adverse neuronal and white matter changes present in the FGR newborn piglet brain. These findings could not be reproduced using MSCs alone. These results demonstrate cECFC treatment exerts beneficial effects on multiple cellular components in the FGR brain and may act as a neuroprotectant.
format	article
author	Kirat K. Chand Jatin Patel S. T. Bjorkman Seen-Ling Sim Stephanie M. Miller Elliot Teo Lara Jones Jane Sun Paul B. Colditz Kiarash Khosrotehrani Julie A. Wixey
author_facet	Kirat K. Chand Jatin Patel S. T. Bjorkman Seen-Ling Sim Stephanie M. Miller Elliot Teo Lara Jones Jane Sun Paul B. Colditz Kiarash Khosrotehrani Julie A. Wixey
author_sort	Kirat K. Chand
title	Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
title_short	Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
title_full	Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
title_fullStr	Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
title_full_unstemmed	Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
title_sort	combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8b09f839fb949199093e3762d588305
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Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

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