Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover

Decreased expression of BAG3 in the heart is associated with contractile dysfunction and heart failure. Here the authors show that this is due to decreased BAG3-dependent sarcomere protein turnover, which impairs mechanical function, and that sarcomere force-generating capacity is restored with BAG3...

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Auteurs principaux:	Thomas G. Martin, Valerie D. Myers, Praveen Dubey, Shubham Dubey, Edith Perez, Christine S. Moravec, Monte S. Willis, Arthur M. Feldman, Jonathan A. Kirk
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e8b11b6fcce64e39a9fa3c8e82869801
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spelling	oai:doaj.org-article:e8b11b6fcce64e39a9fa3c8e828698012021-12-02T14:58:51ZCardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover10.1038/s41467-021-23272-z2041-1723https://doaj.org/article/e8b11b6fcce64e39a9fa3c8e828698012021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23272-zhttps://doaj.org/toc/2041-1723Decreased expression of BAG3 in the heart is associated with contractile dysfunction and heart failure. Here the authors show that this is due to decreased BAG3-dependent sarcomere protein turnover, which impairs mechanical function, and that sarcomere force-generating capacity is restored with BAG3 gene therapy.Thomas G. MartinValerie D. MyersPraveen DubeyShubham DubeyEdith PerezChristine S. MoravecMonte S. WillisArthur M. FeldmanJonathan A. KirkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas G. Martin Valerie D. Myers Praveen Dubey Shubham Dubey Edith Perez Christine S. Moravec Monte S. Willis Arthur M. Feldman Jonathan A. Kirk Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover
description	Decreased expression of BAG3 in the heart is associated with contractile dysfunction and heart failure. Here the authors show that this is due to decreased BAG3-dependent sarcomere protein turnover, which impairs mechanical function, and that sarcomere force-generating capacity is restored with BAG3 gene therapy.
format	article
author	Thomas G. Martin Valerie D. Myers Praveen Dubey Shubham Dubey Edith Perez Christine S. Moravec Monte S. Willis Arthur M. Feldman Jonathan A. Kirk
author_facet	Thomas G. Martin Valerie D. Myers Praveen Dubey Shubham Dubey Edith Perez Christine S. Moravec Monte S. Willis Arthur M. Feldman Jonathan A. Kirk
author_sort	Thomas G. Martin
title	Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover
title_short	Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover
title_full	Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover
title_fullStr	Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover
title_full_unstemmed	Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover
title_sort	cardiomyocyte contractile impairment in heart failure results from reduced bag3-mediated sarcomeric protein turnover
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8b11b6fcce64e39a9fa3c8e82869801
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Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover

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