Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women

Vitamin D: Supplementation offers glimmer of benefit Vitamin D supplementation may help lower the expression of a cancer-associated gene in breast tissue, according to a preliminary trial. Anne McTiernan, Larissa Korde and colleagues at the Fred Hutchinson Cancer Research Center in Seattle, Washingt...

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Autores principales:	Caitlin Mason, Lei Wang, Catherine Duggan, Ikuyo Imayama, Sushma S. Thomas, Ching-Yun Wang, Larissa A. Korde, Anne McTiernan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e8b1251e044044e5a405d275e6b76e29
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spelling	oai:doaj.org-article:e8b1251e044044e5a405d275e6b76e292021-12-02T11:51:08ZGene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women10.1038/s41523-017-0019-52374-4677https://doaj.org/article/e8b1251e044044e5a405d275e6b76e292017-04-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0019-5https://doaj.org/toc/2374-4677Vitamin D: Supplementation offers glimmer of benefit Vitamin D supplementation may help lower the expression of a cancer-associated gene in breast tissue, according to a preliminary trial. Anne McTiernan, Larissa Korde and colleagues at the Fred Hutchinson Cancer Research Center in Seattle, Washington, USA, ran a 12-month randomized clinical study in which 79 overweight postmenopausal women received either daily vitamin D pills or a placebo while concurrently completing a behavioral weight loss program. At the end of the year-long trial, vitamin D seemed to have no effect on the expression of five cancer-linked genes in either breast or fat tissues compared to placebo. However, women taking the vitamin supplements whose vitamin D levels went up showed a significant drop in their breast tissue in the expression of one cancer-related gene compared to women whose vitamin levels didn’t rise despite the daily pills.Caitlin MasonLei WangCatherine DugganIkuyo ImayamaSushma S. ThomasChing-Yun WangLarissa A. KordeAnne McTiernanNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Caitlin Mason Lei Wang Catherine Duggan Ikuyo Imayama Sushma S. Thomas Ching-Yun Wang Larissa A. Korde Anne McTiernan Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women
description	Vitamin D: Supplementation offers glimmer of benefit Vitamin D supplementation may help lower the expression of a cancer-associated gene in breast tissue, according to a preliminary trial. Anne McTiernan, Larissa Korde and colleagues at the Fred Hutchinson Cancer Research Center in Seattle, Washington, USA, ran a 12-month randomized clinical study in which 79 overweight postmenopausal women received either daily vitamin D pills or a placebo while concurrently completing a behavioral weight loss program. At the end of the year-long trial, vitamin D seemed to have no effect on the expression of five cancer-linked genes in either breast or fat tissues compared to placebo. However, women taking the vitamin supplements whose vitamin D levels went up showed a significant drop in their breast tissue in the expression of one cancer-related gene compared to women whose vitamin levels didn’t rise despite the daily pills.
format	article
author	Caitlin Mason Lei Wang Catherine Duggan Ikuyo Imayama Sushma S. Thomas Ching-Yun Wang Larissa A. Korde Anne McTiernan
author_facet	Caitlin Mason Lei Wang Catherine Duggan Ikuyo Imayama Sushma S. Thomas Ching-Yun Wang Larissa A. Korde Anne McTiernan
author_sort	Caitlin Mason
title	Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women
title_short	Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women
title_full	Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women
title_fullStr	Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women
title_full_unstemmed	Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women
title_sort	gene expression in breast and adipose tissue after 12 months of weight loss and vitamin d supplementation in postmenopausal women
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e8b1251e044044e5a405d275e6b76e29
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Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women

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