Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.

Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fa...

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Autores principales:	Thomas Briese, Janusz T Paweska, Laura K McMullan, Stephen K Hutchison, Craig Street, Gustavo Palacios, Marina L Khristova, Jacqueline Weyer, Robert Swanepoel, Michael Egholm, Stuart T Nichol, W Ian Lipkin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e8b16706666a4557a70c2fbcadf46c8c
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spelling	oai:doaj.org-article:e8b16706666a4557a70c2fbcadf46c8c2021-11-25T05:47:54ZGenetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.1553-73661553-737410.1371/journal.ppat.1000455https://doaj.org/article/e8b16706666a4557a70c2fbcadf46c8c2009-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19478873/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fatality rate of 80% (4/5 cases). Unbiased pyrosequencing of RNA extracts from serum and tissues of outbreak victims enabled identification and detailed phylogenetic characterization within 72 hours of sample receipt. Full genome analyses of LUJV showed it to be unique and branching off the ancestral node of the Old World arenaviruses. The virus G1 glycoprotein sequence was highly diverse and almost equidistant from that of other Old World and New World arenaviruses, consistent with a potential distinctive receptor tropism. LUJV is a novel, genetically distinct, highly pathogenic arenavirus.Thomas BrieseJanusz T PaweskaLaura K McMullanStephen K HutchisonCraig StreetGustavo PalaciosMarina L KhristovaJacqueline WeyerRobert SwanepoelMichael EgholmStuart T NicholW Ian LipkinPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 5, p e1000455 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Thomas Briese Janusz T Paweska Laura K McMullan Stephen K Hutchison Craig Street Gustavo Palacios Marina L Khristova Jacqueline Weyer Robert Swanepoel Michael Egholm Stuart T Nichol W Ian Lipkin Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.
description	Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fatality rate of 80% (4/5 cases). Unbiased pyrosequencing of RNA extracts from serum and tissues of outbreak victims enabled identification and detailed phylogenetic characterization within 72 hours of sample receipt. Full genome analyses of LUJV showed it to be unique and branching off the ancestral node of the Old World arenaviruses. The virus G1 glycoprotein sequence was highly diverse and almost equidistant from that of other Old World and New World arenaviruses, consistent with a potential distinctive receptor tropism. LUJV is a novel, genetically distinct, highly pathogenic arenavirus.
format	article
author	Thomas Briese Janusz T Paweska Laura K McMullan Stephen K Hutchison Craig Street Gustavo Palacios Marina L Khristova Jacqueline Weyer Robert Swanepoel Michael Egholm Stuart T Nichol W Ian Lipkin
author_facet	Thomas Briese Janusz T Paweska Laura K McMullan Stephen K Hutchison Craig Street Gustavo Palacios Marina L Khristova Jacqueline Weyer Robert Swanepoel Michael Egholm Stuart T Nichol W Ian Lipkin
author_sort	Thomas Briese
title	Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.
title_short	Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.
title_full	Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.
title_fullStr	Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.
title_full_unstemmed	Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.
title_sort	genetic detection and characterization of lujo virus, a new hemorrhagic fever-associated arenavirus from southern africa.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/e8b16706666a4557a70c2fbcadf46c8c
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Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa.

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