Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

COBRA1 is a BRCA1-binding protein and, as part of the negative elongation factor, regulates RNA polymerase II pausing and transcription elongation. Here, the authors show that tissue-specific deletion of mouse Cobra1 inhibits postnatal mammary gland development and that the mammary defects can be re...

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Autores principales:	Sreejith J. Nair, Xiaowen Zhang, Huai-Chin Chiang, Md Jamiul Jahid, Yao Wang, Paula Garza, Craig April, Neeraj Salathia, Tapahsama Banerjee, Fahad S. Alenazi, Jianhua Ruan, Jian-Bing Fan, Jeffrey D. Parvin, Victor X. Jin, Yanfen Hu, Rong Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8b1af6dbaf6435f9056729025693328
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spelling	oai:doaj.org-article:e8b1af6dbaf6435f90567290256933282021-12-02T17:31:19ZGenetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development10.1038/ncomms109132041-1723https://doaj.org/article/e8b1af6dbaf6435f90567290256933282016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10913https://doaj.org/toc/2041-1723COBRA1 is a BRCA1-binding protein and, as part of the negative elongation factor, regulates RNA polymerase II pausing and transcription elongation. Here, the authors show that tissue-specific deletion of mouse Cobra1 inhibits postnatal mammary gland development and that the mammary defects can be rescued by additional deletion of Brca1in a DNA repair-independent manner.Sreejith J. NairXiaowen ZhangHuai-Chin ChiangMd Jamiul JahidYao WangPaula GarzaCraig AprilNeeraj SalathiaTapahsama BanerjeeFahad S. AlenaziJianhua RuanJian-Bing FanJeffrey D. ParvinVictor X. JinYanfen HuRong LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sreejith J. Nair Xiaowen Zhang Huai-Chin Chiang Md Jamiul Jahid Yao Wang Paula Garza Craig April Neeraj Salathia Tapahsama Banerjee Fahad S. Alenazi Jianhua Ruan Jian-Bing Fan Jeffrey D. Parvin Victor X. Jin Yanfen Hu Rong Li Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development
description	COBRA1 is a BRCA1-binding protein and, as part of the negative elongation factor, regulates RNA polymerase II pausing and transcription elongation. Here, the authors show that tissue-specific deletion of mouse Cobra1 inhibits postnatal mammary gland development and that the mammary defects can be rescued by additional deletion of Brca1in a DNA repair-independent manner.
format	article
author	Sreejith J. Nair Xiaowen Zhang Huai-Chin Chiang Md Jamiul Jahid Yao Wang Paula Garza Craig April Neeraj Salathia Tapahsama Banerjee Fahad S. Alenazi Jianhua Ruan Jian-Bing Fan Jeffrey D. Parvin Victor X. Jin Yanfen Hu Rong Li
author_facet	Sreejith J. Nair Xiaowen Zhang Huai-Chin Chiang Md Jamiul Jahid Yao Wang Paula Garza Craig April Neeraj Salathia Tapahsama Banerjee Fahad S. Alenazi Jianhua Ruan Jian-Bing Fan Jeffrey D. Parvin Victor X. Jin Yanfen Hu Rong Li
author_sort	Sreejith J. Nair
title	Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development
title_short	Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development
title_full	Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development
title_fullStr	Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development
title_full_unstemmed	Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development
title_sort	genetic suppression reveals dna repair-independent antagonism between brca1 and cobra1 in mammary gland development
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e8b1af6dbaf6435f9056729025693328
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Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

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