A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

Syncrip is a conserved RNA-binding protein that mediates selective miRNA loading into cell-secreted exosomes, which is important for cell–cell communication. Here the authors provide mechanistic insights into how Syncrip recognises its target miRNAs by combining NMR and crystallography.

Guardado en:

Detalles Bibliográficos
Autores principales:	Fruzsina Hobor, Andre Dallmann, Neil J. Ball, Carla Cicchini, Cecilia Battistelli, Roksana W. Ogrodowicz, Evangelos Christodoulou, Stephen R. Martin, Alfredo Castello, Marco Tripodi, Ian A. Taylor, Andres Ramos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8b59054a2c04f5fa6bc358e84c2ef95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e8b59054a2c04f5fa6bc358e84c2ef95
record_format	dspace
spelling	oai:doaj.org-article:e8b59054a2c04f5fa6bc358e84c2ef952021-12-02T17:32:14ZA cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets10.1038/s41467-018-03182-32041-1723https://doaj.org/article/e8b59054a2c04f5fa6bc358e84c2ef952018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03182-3https://doaj.org/toc/2041-1723Syncrip is a conserved RNA-binding protein that mediates selective miRNA loading into cell-secreted exosomes, which is important for cell–cell communication. Here the authors provide mechanistic insights into how Syncrip recognises its target miRNAs by combining NMR and crystallography.Fruzsina HoborAndre DallmannNeil J. BallCarla CicchiniCecilia BattistelliRoksana W. OgrodowiczEvangelos ChristodoulouStephen R. MartinAlfredo CastelloMarco TripodiIan A. TaylorAndres RamosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fruzsina Hobor Andre Dallmann Neil J. Ball Carla Cicchini Cecilia Battistelli Roksana W. Ogrodowicz Evangelos Christodoulou Stephen R. Martin Alfredo Castello Marco Tripodi Ian A. Taylor Andres Ramos A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
description	Syncrip is a conserved RNA-binding protein that mediates selective miRNA loading into cell-secreted exosomes, which is important for cell–cell communication. Here the authors provide mechanistic insights into how Syncrip recognises its target miRNAs by combining NMR and crystallography.
format	article
author	Fruzsina Hobor Andre Dallmann Neil J. Ball Carla Cicchini Cecilia Battistelli Roksana W. Ogrodowicz Evangelos Christodoulou Stephen R. Martin Alfredo Castello Marco Tripodi Ian A. Taylor Andres Ramos
author_facet	Fruzsina Hobor Andre Dallmann Neil J. Ball Carla Cicchini Cecilia Battistelli Roksana W. Ogrodowicz Evangelos Christodoulou Stephen R. Martin Alfredo Castello Marco Tripodi Ian A. Taylor Andres Ramos
author_sort	Fruzsina Hobor
title	A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
title_short	A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
title_full	A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
title_fullStr	A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
title_full_unstemmed	A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
title_sort	cryptic rna-binding domain mediates syncrip recognition and exosomal partitioning of mirna targets
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e8b59054a2c04f5fa6bc358e84c2ef95
work_keys_str_mv	AT fruzsinahobor acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT andredallmann acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT neiljball acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT carlacicchini acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT ceciliabattistelli acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT roksanawogrodowicz acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT evangeloschristodoulou acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT stephenrmartin acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT alfredocastello acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT marcotripodi acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT ianataylor acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT andresramos acrypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT fruzsinahobor crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT andredallmann crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT neiljball crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT carlacicchini crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT ceciliabattistelli crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT roksanawogrodowicz crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT evangeloschristodoulou crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT stephenrmartin crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT alfredocastello crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT marcotripodi crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT ianataylor crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets AT andresramos crypticrnabindingdomainmediatessyncriprecognitionandexosomalpartitioningofmirnatargets
_version_	1718380404303462400

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

Ejemplares similares