A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

Syncrip is a conserved RNA-binding protein that mediates selective miRNA loading into cell-secreted exosomes, which is important for cell–cell communication. Here the authors provide mechanistic insights into how Syncrip recognises its target miRNAs by combining NMR and crystallography.

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Detalles Bibliográficos
Autores principales: Fruzsina Hobor, Andre Dallmann, Neil J. Ball, Carla Cicchini, Cecilia Battistelli, Roksana W. Ogrodowicz, Evangelos Christodoulou, Stephen R. Martin, Alfredo Castello, Marco Tripodi, Ian A. Taylor, Andres Ramos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e8b59054a2c04f5fa6bc358e84c2ef95
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