Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

<h4>Context</h4>Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the Wnt/β-catenin sig...

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Autores principales: Sébastien Gaujoux, Constanze Hantel, Pierre Launay, Stéphane Bonnet, Karine Perlemoine, Lucile Lefèvre, Marine Guillaud-Bataille, Felix Beuschlein, Frédérique Tissier, Jérôme Bertherat, Marthe Rizk-Rabin, Bruno Ragazzon
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/e8baa0d2cca04cffbfe551e33e213bea
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