An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Aging impacts lung functionality and makes it more susceptible to chronic diseases. Combining proteomics and single cell transcriptomics, the authors chart molecular and cellular changes in the aging mouse lung, discover aging hallmarks, and predict the cellular sources of regulated proteins.
Saved in:
| Main Authors: | Ilias Angelidis, Lukas M. Simon, Isis E. Fernandez, Maximilian Strunz, Christoph H. Mayr, Flavia R. Greiffo, George Tsitsiridis, Meshal Ansari, Elisabeth Graf, Tim-Matthias Strom, Monica Nagendran, Tushar Desai, Oliver Eickelberg, Matthias Mann, Fabian J. Theis, Herbert B. Schiller |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2019
|
| Subjects: | |
| Online Access: | https://doaj.org/article/e8bbc178370d42f0a7884140d62b6b59 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
by: Maximilian Strunz, et al.
Published: (2020) -
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
by: Adrian Fischer, et al.
Published: (2020) -
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’
by: David S. Fischer, et al.
Published: (2021) -
A chelicerate Wnt gene expression atlas: novel insights into the complexity of arthropod Wnt-patterning
by: Ralf Janssen, et al.
Published: (2021) -
Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin
by: Beatrice Dyring-Andersen, et al.
Published: (2020)