Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells

T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the function of key regulatory elements and genes in v...

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Autores principales:	Chun Su, Matthew E. Johnson, Annabel Torres, Rajan M. Thomas, Elisabetta Manduchi, Prabhat Sharma, Parul Mehra, Carole Le Coz, Michelle E. Leonard, Sumei Lu, Kenyaita M. Hodge, Alessandra Chesi, James Pippin, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8bc69a5fa22479099c81e256d349a2f
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spelling	oai:doaj.org-article:e8bc69a5fa22479099c81e256d349a2f2021-12-02T16:31:47ZMapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells10.1038/s41467-020-17089-52041-1723https://doaj.org/article/e8bc69a5fa22479099c81e256d349a2f2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17089-5https://doaj.org/toc/2041-1723T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the function of key regulatory elements and genes in vitro.Chun SuMatthew E. JohnsonAnnabel TorresRajan M. ThomasElisabetta ManduchiPrabhat SharmaParul MehraCarole Le CozMichelle E. LeonardSumei LuKenyaita M. HodgeAlessandra ChesiJames PippinNeil RombergStruan F. A. GrantAndrew D. WellsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun Su Matthew E. Johnson Annabel Torres Rajan M. Thomas Elisabetta Manduchi Prabhat Sharma Parul Mehra Carole Le Coz Michelle E. Leonard Sumei Lu Kenyaita M. Hodge Alessandra Chesi James Pippin Neil Romberg Struan F. A. Grant Andrew D. Wells Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
description	T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the function of key regulatory elements and genes in vitro.
format	article
author	Chun Su Matthew E. Johnson Annabel Torres Rajan M. Thomas Elisabetta Manduchi Prabhat Sharma Parul Mehra Carole Le Coz Michelle E. Leonard Sumei Lu Kenyaita M. Hodge Alessandra Chesi James Pippin Neil Romberg Struan F. A. Grant Andrew D. Wells
author_facet	Chun Su Matthew E. Johnson Annabel Torres Rajan M. Thomas Elisabetta Manduchi Prabhat Sharma Parul Mehra Carole Le Coz Michelle E. Leonard Sumei Lu Kenyaita M. Hodge Alessandra Chesi James Pippin Neil Romberg Struan F. A. Grant Andrew D. Wells
author_sort	Chun Su
title	Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
title_short	Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
title_full	Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
title_fullStr	Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
title_full_unstemmed	Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
title_sort	mapping effector genes at lupus gwas loci using promoter capture-c in follicular helper t cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e8bc69a5fa22479099c81e256d349a2f
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Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells

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