Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during replication, a process that requires the ATPase-dependent activity of the MCM complex. Using cryo-EM reconstructions of the CMG complex in different conformations, the authors propose a model where the N-terminal and AAA+ domains of MCM work in co...

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Autores principales:	Ferdos Abid Ali, Ludovic Renault, Julian Gannon, Hailey L. Gahlon, Abhay Kotecha, Jin Chuan Zhou, David Rueda, Alessandro Costa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8bcf31cfc344c0caf66a04f100182fe
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spelling	oai:doaj.org-article:e8bcf31cfc344c0caf66a04f100182fe2021-12-02T17:33:20ZCryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate10.1038/ncomms107082041-1723https://doaj.org/article/e8bcf31cfc344c0caf66a04f100182fe2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10708https://doaj.org/toc/2041-1723The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during replication, a process that requires the ATPase-dependent activity of the MCM complex. Using cryo-EM reconstructions of the CMG complex in different conformations, the authors propose a model where the N-terminal and AAA+ domains of MCM work in concert to translocate along DNA.Ferdos Abid AliLudovic RenaultJulian GannonHailey L. GahlonAbhay KotechaJin Chuan ZhouDavid RuedaAlessandro CostaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ferdos Abid Ali Ludovic Renault Julian Gannon Hailey L. Gahlon Abhay Kotecha Jin Chuan Zhou David Rueda Alessandro Costa Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
description	The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during replication, a process that requires the ATPase-dependent activity of the MCM complex. Using cryo-EM reconstructions of the CMG complex in different conformations, the authors propose a model where the N-terminal and AAA+ domains of MCM work in concert to translocate along DNA.
format	article
author	Ferdos Abid Ali Ludovic Renault Julian Gannon Hailey L. Gahlon Abhay Kotecha Jin Chuan Zhou David Rueda Alessandro Costa
author_facet	Ferdos Abid Ali Ludovic Renault Julian Gannon Hailey L. Gahlon Abhay Kotecha Jin Chuan Zhou David Rueda Alessandro Costa
author_sort	Ferdos Abid Ali
title	Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
title_short	Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
title_full	Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
title_fullStr	Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
title_full_unstemmed	Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate
title_sort	cryo-em structures of the eukaryotic replicative helicase bound to a translocation substrate
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e8bcf31cfc344c0caf66a04f100182fe
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Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

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