Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during replication, a process that requires the ATPase-dependent activity of the MCM complex. Using cryo-EM reconstructions of the CMG complex in different conformations, the authors propose a model where the N-terminal and AAA+ domains of MCM work in co...

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Autores principales: Ferdos Abid Ali, Ludovic Renault, Julian Gannon, Hailey L. Gahlon, Abhay Kotecha, Jin Chuan Zhou, David Rueda, Alessandro Costa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/e8bcf31cfc344c0caf66a04f100182fe
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