Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes

Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Chondral and osteochondral defects affect a large number of p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bhardwaj G, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Chondrocytes XanoMatrixTM Cell Culture Substrates and Biomimetic Scaffolds Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e8bcffd8378946e4b3a3dd4a6f44da5d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e8bcffd8378946e4b3a3dd4a6f44da5d
record_format	dspace
spelling	oai:doaj.org-article:e8bcffd8378946e4b3a3dd4a6f44da5d2021-12-02T11:01:35ZEnhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes1178-2013https://doaj.org/article/e8bcffd8378946e4b3a3dd4a6f44da5d2016-02-01T00:00:00Zhttps://www.dovepress.com/enhanced-chondrocyte-culture-and-growth-on-biologically-inspired-nanof-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Chondral and osteochondral defects affect a large number of people in which treatment options are currently limited. Due to its ability to mimic the natural nanofibrous structure of cartilage, this current in vitro study aimed at introducing a new scaffold, called XanoMatrix™, for cartilage regeneration. In addition, this same scaffold is introduced here as a new substrate onto which to study chondrocyte functions. Current studies on chondrocyte functions are limited due to nonbiologically inspired cell culture substrates. With its polyethylene terephthalate and cellulose acetate composition, good mechanical properties and nanofibrous structure resembling an extracellular matrix, XanoMatrix offers an ideal surface for chondrocyte growth and proliferation. This current study demonstrated that the XanoMatrix scaffolds promote chondrocyte growth and proliferation as compared with the Corning and Falcon surfaces normally used for chondrocyte cell culture. The XanoMatrix scaffolds also have greater hydrophobicity, three-dimensional surface area, and greater tensile strength, making them ideal candidates for alternative treatment options for chondral and osteochondral defects as well as cell culture substrates to study chondrocyte functions. Keywords: chondrocytes, XanoMatrix™, cell culture, substrates, biomimetic scaffoldsBhardwaj GWebster TJDove Medical PressarticleChondrocytesXanoMatrixTMCell Culture Substrates and Biomimetic ScaffoldsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss Issue 1, Pp 479-483 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chondrocytes XanoMatrixTM Cell Culture Substrates and Biomimetic Scaffolds Medicine (General) R5-920
spellingShingle	Chondrocytes XanoMatrixTM Cell Culture Substrates and Biomimetic Scaffolds Medicine (General) R5-920 Bhardwaj G Webster TJ Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
description	Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Chondral and osteochondral defects affect a large number of people in which treatment options are currently limited. Due to its ability to mimic the natural nanofibrous structure of cartilage, this current in vitro study aimed at introducing a new scaffold, called XanoMatrix™, for cartilage regeneration. In addition, this same scaffold is introduced here as a new substrate onto which to study chondrocyte functions. Current studies on chondrocyte functions are limited due to nonbiologically inspired cell culture substrates. With its polyethylene terephthalate and cellulose acetate composition, good mechanical properties and nanofibrous structure resembling an extracellular matrix, XanoMatrix offers an ideal surface for chondrocyte growth and proliferation. This current study demonstrated that the XanoMatrix scaffolds promote chondrocyte growth and proliferation as compared with the Corning and Falcon surfaces normally used for chondrocyte cell culture. The XanoMatrix scaffolds also have greater hydrophobicity, three-dimensional surface area, and greater tensile strength, making them ideal candidates for alternative treatment options for chondral and osteochondral defects as well as cell culture substrates to study chondrocyte functions. Keywords: chondrocytes, XanoMatrix™, cell culture, substrates, biomimetic scaffolds
format	article
author	Bhardwaj G Webster TJ
author_facet	Bhardwaj G Webster TJ
author_sort	Bhardwaj G
title	Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
title_short	Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
title_full	Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
title_fullStr	Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
title_full_unstemmed	Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
title_sort	enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/e8bcffd8378946e4b3a3dd4a6f44da5d
work_keys_str_mv	AT bhardwajg enhancedchondrocytecultureandgrowthonbiologicallyinspirednanofibrouscellculturedishes AT webstertj enhancedchondrocytecultureandgrowthonbiologicallyinspirednanofibrouscellculturedishes
_version_	1718396386133671936

Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes

Ejemplares similares