A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration

Abstract A 7‐year‐old spayed female Scottish Fold cat presented with a 4‐week history of anorexia, weight loss and vomiting. Abdominal ultrasonography revealed a jejunal mass and a slightly enlarged jejunal lymph node. A fine‐needle aspiration of the mass revealed many round cells with multiple smal...

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Autores principales:	Makoto Akiyoshi, Masami Akiyoshi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Chemotherapy gastrointestinal tract postoperative management lymphoma lymphosarcoma Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/e8c494b13f8145378d24e9840a2ece1e
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spelling	oai:doaj.org-article:e8c494b13f8145378d24e9840a2ece1e2021-11-19T17:14:25ZA case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration2053-109510.1002/vms3.612https://doaj.org/article/e8c494b13f8145378d24e9840a2ece1e2021-11-01T00:00:00Zhttps://doi.org/10.1002/vms3.612https://doaj.org/toc/2053-1095Abstract A 7‐year‐old spayed female Scottish Fold cat presented with a 4‐week history of anorexia, weight loss and vomiting. Abdominal ultrasonography revealed a jejunal mass and a slightly enlarged jejunal lymph node. A fine‐needle aspiration of the mass revealed many round cells with multiple small intracytoplasmic magenta granules. The mass was diagnosed as a large granular lymphocyte (LGL) lymphoma based on cytology. The LGL lymphoma was completely resected via open surgery. The histologic and cytologic evaluations showed no neoplastic findings in the jejunal lymph node, liver, spleen, kidney or bone marrow. The LGL lymphoma was localized to the jejunum. Postoperatively, the cat received chemotherapy with nimustine, L‐asparaginase and prednisolone. The cat is currently receiving nimustine every 6 weeks, without adverse events, and treatment has been administrated a total of 18 times up until day 552. The cat is in a good condition, and the LGL lymphoma has not recurred. Nimustine should be considered one of the effective chemotherapeutic agents in the treatment of feline LGL lymphoma cases in the future.Makoto AkiyoshiMasami AkiyoshiWileyarticleChemotherapygastrointestinal tractpostoperative managementlymphomalymphosarcomaVeterinary medicineSF600-1100ENVeterinary Medicine and Science, Vol 7, Iss 6, Pp 2103-2107 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemotherapy gastrointestinal tract postoperative management lymphoma lymphosarcoma Veterinary medicine SF600-1100
spellingShingle	Chemotherapy gastrointestinal tract postoperative management lymphoma lymphosarcoma Veterinary medicine SF600-1100 Makoto Akiyoshi Masami Akiyoshi A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration
description	Abstract A 7‐year‐old spayed female Scottish Fold cat presented with a 4‐week history of anorexia, weight loss and vomiting. Abdominal ultrasonography revealed a jejunal mass and a slightly enlarged jejunal lymph node. A fine‐needle aspiration of the mass revealed many round cells with multiple small intracytoplasmic magenta granules. The mass was diagnosed as a large granular lymphocyte (LGL) lymphoma based on cytology. The LGL lymphoma was completely resected via open surgery. The histologic and cytologic evaluations showed no neoplastic findings in the jejunal lymph node, liver, spleen, kidney or bone marrow. The LGL lymphoma was localized to the jejunum. Postoperatively, the cat received chemotherapy with nimustine, L‐asparaginase and prednisolone. The cat is currently receiving nimustine every 6 weeks, without adverse events, and treatment has been administrated a total of 18 times up until day 552. The cat is in a good condition, and the LGL lymphoma has not recurred. Nimustine should be considered one of the effective chemotherapeutic agents in the treatment of feline LGL lymphoma cases in the future.
format	article
author	Makoto Akiyoshi Masami Akiyoshi
author_facet	Makoto Akiyoshi Masami Akiyoshi
author_sort	Makoto Akiyoshi
title	A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration
title_short	A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration
title_full	A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration
title_fullStr	A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration
title_full_unstemmed	A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration
title_sort	case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e8c494b13f8145378d24e9840a2ece1e
work_keys_str_mv	AT makotoakiyoshi acaseoffelinelargegranularlymphocytelymphomawithcompleteremissionandlongsurvivalbysurgicalresectionandadjuvantnimustineadministration AT masamiakiyoshi acaseoffelinelargegranularlymphocytelymphomawithcompleteremissionandlongsurvivalbysurgicalresectionandadjuvantnimustineadministration AT makotoakiyoshi caseoffelinelargegranularlymphocytelymphomawithcompleteremissionandlongsurvivalbysurgicalresectionandadjuvantnimustineadministration AT masamiakiyoshi caseoffelinelargegranularlymphocytelymphomawithcompleteremissionandlongsurvivalbysurgicalresectionandadjuvantnimustineadministration
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A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration

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