Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study

Vaishnavi Kundel,1 Daniel Lehane,2 Sarayu Ramachandran,3 Zahi Fayad,3 Philip Robson,3 Neomi Shah,1 Venkatesh Mani3 1Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2University of Rochester School of Medicin...

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Autores principales:	Kundel V, Lehane D, Ramachandran S, Fayad Z, Robson P, Shah N, Mani V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	sleep apnea osa pet mri visceral adipose tissue Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/e8c4e739ca0346a9a0be743a4984b817
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spelling	oai:doaj.org-article:e8c4e739ca0346a9a0be743a4984b8172021-12-02T17:26:25ZMeasuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study1179-1608https://doaj.org/article/e8c4e739ca0346a9a0be743a4984b8172021-10-01T00:00:00Zhttps://www.dovepress.com/measuring-visceral-adipose-tissue-metabolic-activity-in-sleep-apnea-ut-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Vaishnavi Kundel,1 Daniel Lehane,2 Sarayu Ramachandran,3 Zahi Fayad,3 Philip Robson,3 Neomi Shah,1 Venkatesh Mani3 1Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; 3Department of Radiology, BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USACorrespondence: Vaishnavi KundelAssistant Professor of Medicine, Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1232, New York, NY, 10029, USATel +1 212-241-6564Email Vaishnavi.kundel@mssm.eduPurpose: Visceral adipose tissue (VAT) is proinflammatory and is associated with cardiovascular (CV) disease. We investigated the relationship between obstructive sleep apnea (OSA) and visceral adipose tissue (VAT) metabolic activity in a pilot group of patients using positron-emission tomography/magnetic resonance imaging (PET/MRI) with 18F-fluorodeoxyglucose (FDG) tracer as a novel marker of adipose tissue inflammation.Patients and Methods: We analyzed patients from an ongoing study, recruiting those with newly diagnosed, untreated OSA (Respiratory Disturbance Index [RDI] ≥ 5), using home sleep apnea testing (WatchPAT-200 Central-Plus). PET/MRI scans were acquired before continuous positive airway pressure (CPAP)-initiation, and after 3 months of CPAP therapy. Adipose tissue metabolic activity (18F-FDG-uptake) was measured using standardized uptake values (SUV) within the adipose tissue depots. The primary outcome was VAT SUVmean, and secondary outcomes included VAT volume, and subcutaneous adipose tissue (SAT) volume/SUVmean. Reproducibility and reliability of outcome measures were analyzed using intraclass correlation coefficients (ICC). Multivariable linear regression was used to evaluate the association between OSA and primary/secondary outcomes.Results: Our analytical sample (n = 16) was 81% male (mean age 47 ± 15 years, mean BMI of 29.9 ± 4.8kg/m2). About 56% had moderate to severe OSA (mean RDI 23 ± 6 events/hour), and 50% were adherent to CPAP. We demonstrated excellent inter/intra-rater reliability and reproducibility for the primary and secondary outcomes. Patients with moderate-to-severe OSA had a higher VAT SUV mean compared to those with mild OSA (0.795 ± 0.154 vs 0.602 ± 0.19, p = 0.04). OSA severity was positively associated with VAT SUVmean (primary outcome), adjusted for age and BMI (B [SE] = 0.013 ± 0.005, p = 0.03). Change in VAT volume was inversely correlated with CPAP adherence in unadjusted analysis (B [SE] = − 48.4 ± 18.7, p = 0.02).Conclusion: Derangements in VAT metabolic activity are implicated in adverse cardiometabolic outcomes and may be one of the key drivers of CV risk in OSA. Our results are hypothesis-generating, and suggest that VAT should be investigated in future studies using multi-modal imaging to understand its role as a potential mediator of adverse cardiometabolic risk in OSA.Keywords: sleep apnea, OSA, PET, MRI, visceral adipose tissueKundel VLehane DRamachandran SFayad ZRobson PShah NMani VDove Medical Pressarticlesleep apneaosapetmrivisceral adipose tissuePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1943-1953 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep apnea osa pet mri visceral adipose tissue Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	sleep apnea osa pet mri visceral adipose tissue Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Kundel V Lehane D Ramachandran S Fayad Z Robson P Shah N Mani V Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study
description	Vaishnavi Kundel,1 Daniel Lehane,2 Sarayu Ramachandran,3 Zahi Fayad,3 Philip Robson,3 Neomi Shah,1 Venkatesh Mani3 1Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; 3Department of Radiology, BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USACorrespondence: Vaishnavi KundelAssistant Professor of Medicine, Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1232, New York, NY, 10029, USATel +1 212-241-6564Email Vaishnavi.kundel@mssm.eduPurpose: Visceral adipose tissue (VAT) is proinflammatory and is associated with cardiovascular (CV) disease. We investigated the relationship between obstructive sleep apnea (OSA) and visceral adipose tissue (VAT) metabolic activity in a pilot group of patients using positron-emission tomography/magnetic resonance imaging (PET/MRI) with 18F-fluorodeoxyglucose (FDG) tracer as a novel marker of adipose tissue inflammation.Patients and Methods: We analyzed patients from an ongoing study, recruiting those with newly diagnosed, untreated OSA (Respiratory Disturbance Index [RDI] ≥ 5), using home sleep apnea testing (WatchPAT-200 Central-Plus). PET/MRI scans were acquired before continuous positive airway pressure (CPAP)-initiation, and after 3 months of CPAP therapy. Adipose tissue metabolic activity (18F-FDG-uptake) was measured using standardized uptake values (SUV) within the adipose tissue depots. The primary outcome was VAT SUVmean, and secondary outcomes included VAT volume, and subcutaneous adipose tissue (SAT) volume/SUVmean. Reproducibility and reliability of outcome measures were analyzed using intraclass correlation coefficients (ICC). Multivariable linear regression was used to evaluate the association between OSA and primary/secondary outcomes.Results: Our analytical sample (n = 16) was 81% male (mean age 47 ± 15 years, mean BMI of 29.9 ± 4.8kg/m2). About 56% had moderate to severe OSA (mean RDI 23 ± 6 events/hour), and 50% were adherent to CPAP. We demonstrated excellent inter/intra-rater reliability and reproducibility for the primary and secondary outcomes. Patients with moderate-to-severe OSA had a higher VAT SUV mean compared to those with mild OSA (0.795 ± 0.154 vs 0.602 ± 0.19, p = 0.04). OSA severity was positively associated with VAT SUVmean (primary outcome), adjusted for age and BMI (B [SE] = 0.013 ± 0.005, p = 0.03). Change in VAT volume was inversely correlated with CPAP adherence in unadjusted analysis (B [SE] = − 48.4 ± 18.7, p = 0.02).Conclusion: Derangements in VAT metabolic activity are implicated in adverse cardiometabolic outcomes and may be one of the key drivers of CV risk in OSA. Our results are hypothesis-generating, and suggest that VAT should be investigated in future studies using multi-modal imaging to understand its role as a potential mediator of adverse cardiometabolic risk in OSA.Keywords: sleep apnea, OSA, PET, MRI, visceral adipose tissue
format	article
author	Kundel V Lehane D Ramachandran S Fayad Z Robson P Shah N Mani V
author_facet	Kundel V Lehane D Ramachandran S Fayad Z Robson P Shah N Mani V
author_sort	Kundel V
title	Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study
title_short	Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study
title_full	Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study
title_fullStr	Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study
title_full_unstemmed	Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study
title_sort	measuring visceral adipose tissue metabolic activity in sleep apnea utilizing hybrid 18f-fdg pet/mri: a pilot study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e8c4e739ca0346a9a0be743a4984b817
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Measuring Visceral Adipose Tissue Metabolic Activity in Sleep Apnea Utilizing Hybrid 18F-FDG PET/MRI: A Pilot Study

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