Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report

Abstract Background Monoclonal gammopathy is a biological reality encountered in approximately 1% of the general population. In the absence of clinical and biological signs, it is considered of undetermined significance; however, it can be a biological signature of a monoclonal lymphocytic or plasma...

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Autores principales:	Hilal Hafian, Hubert Schvartz, Martine Patey, Anne Quinquenel
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Mucosa-associated lymphoid tissue (MALT) Monoclonal gammopathy Lymphoma Oral mucosa Light chain Haemopathy Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/e8c63fa9ddcf4d6083e1b7671353d383
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spelling	oai:doaj.org-article:e8c63fa9ddcf4d6083e1b7671353d3832021-11-28T12:29:28ZPrimary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report10.1186/s12903-021-01960-y1472-6831https://doaj.org/article/e8c63fa9ddcf4d6083e1b7671353d3832021-11-01T00:00:00Zhttps://doi.org/10.1186/s12903-021-01960-yhttps://doaj.org/toc/1472-6831Abstract Background Monoclonal gammopathy is a biological reality encountered in approximately 1% of the general population. In the absence of clinical and biological signs, it is considered of undetermined significance; however, it can be a biological signature of a monoclonal lymphocytic or plasma-cell proliferation. Their localisation to the oral mucosa remains rare and difficult to diagnose, particularly in indolent forms that escape imaging techniques. Case presentation Here, we report the case of a 73-year-old woman with a history of IgM kappa gammopathy followed for 13 years. The patient did not have a chronic infection or an autoimmune disease, and all the biological investigations and radiological explorations were unremarkable during this period. The discovery of a submucosal nodule in the cheek led to the diagnosis of MALT lymphoma and regression of half of the IgM kappa level after resection. The review of the literature shows the dominance of clinical signs (i.e., a mass or swelling) in the diagnosis of primary MALT lymphomas of the oral cavity after surgical resection. Conclusions Our case illustrates the role of examination of the oral cavity in the context of a monoclonal gammopathy. The absence of clinical and radiological evidence in favor of lymphoplasmacytic proliferation, does not exclude a primary indolent MALT lymphoma of the oral mucosa.Hilal HafianHubert SchvartzMartine PateyAnne QuinquenelBMCarticleMucosa-associated lymphoid tissue (MALT)Monoclonal gammopathyLymphomaOral mucosaLight chainHaemopathyDentistryRK1-715ENBMC Oral Health, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mucosa-associated lymphoid tissue (MALT) Monoclonal gammopathy Lymphoma Oral mucosa Light chain Haemopathy Dentistry RK1-715
spellingShingle	Mucosa-associated lymphoid tissue (MALT) Monoclonal gammopathy Lymphoma Oral mucosa Light chain Haemopathy Dentistry RK1-715 Hilal Hafian Hubert Schvartz Martine Patey Anne Quinquenel Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report
description	Abstract Background Monoclonal gammopathy is a biological reality encountered in approximately 1% of the general population. In the absence of clinical and biological signs, it is considered of undetermined significance; however, it can be a biological signature of a monoclonal lymphocytic or plasma-cell proliferation. Their localisation to the oral mucosa remains rare and difficult to diagnose, particularly in indolent forms that escape imaging techniques. Case presentation Here, we report the case of a 73-year-old woman with a history of IgM kappa gammopathy followed for 13 years. The patient did not have a chronic infection or an autoimmune disease, and all the biological investigations and radiological explorations were unremarkable during this period. The discovery of a submucosal nodule in the cheek led to the diagnosis of MALT lymphoma and regression of half of the IgM kappa level after resection. The review of the literature shows the dominance of clinical signs (i.e., a mass or swelling) in the diagnosis of primary MALT lymphomas of the oral cavity after surgical resection. Conclusions Our case illustrates the role of examination of the oral cavity in the context of a monoclonal gammopathy. The absence of clinical and radiological evidence in favor of lymphoplasmacytic proliferation, does not exclude a primary indolent MALT lymphoma of the oral mucosa.
format	article
author	Hilal Hafian Hubert Schvartz Martine Patey Anne Quinquenel
author_facet	Hilal Hafian Hubert Schvartz Martine Patey Anne Quinquenel
author_sort	Hilal Hafian
title	Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report
title_short	Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report
title_full	Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report
title_fullStr	Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report
title_full_unstemmed	Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report
title_sort	primary oral mucosa-associated lymphoid tissue (malt) lymphoma in patient with monoclonale gammopathy: a rare case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e8c63fa9ddcf4d6083e1b7671353d383
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Primary oral mucosa-associated lymphoid tissue (MALT) lymphoma in patient with monoclonale gammopathy: a rare case report

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