Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase
Abstract Our previous studies unexpectedly indicated that the level of serum hepatitis B core antibody (anti-HBc) was positively correlated with the serum alanine aminotransferase (ALT) level. The aim of this study was to determine whether anti-HBc could serve as a potential biomarker for the detect...
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Nature Portfolio
2017
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oai:doaj.org-article:e8c68542a267458287b8868a1a7e39f32021-12-02T15:05:56ZSerum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase10.1038/s41598-017-03102-32045-2322https://doaj.org/article/e8c68542a267458287b8868a1a7e39f32017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03102-3https://doaj.org/toc/2045-2322Abstract Our previous studies unexpectedly indicated that the level of serum hepatitis B core antibody (anti-HBc) was positively correlated with the serum alanine aminotransferase (ALT) level. The aim of this study was to determine whether anti-HBc could serve as a potential biomarker for the detection of liver inflammation in chronic hepatitis B (CHB) patients, especially in patients with normal ALT levels. Serum anti-HBc levels were quantified in 655 treatment-naïve CHB patients, including 45 patients who underwent two liver biopsies (baseline phase and the 78th weeks of antiviral-treatment). Serum anti-HBc levels increased significantly along with the increasing histology activity index (HAI) score. After antiviral-treatment, patients with HAI score reduction had significant decline in serum anti-HBc level. Multivariate analysis showed that anti-HBc was independently associated with moderate-to-severe hepatic inflammation in patients with normal ALT level. Furthermore, serum anti-HBc showed a high diagnostic accuracy for predicting moderate-to-severe inflammation in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative CHB patients with normal ALT levels (area under the curve, AUC = 0.87 and 0.75; respectively). Thus, anti-HBc may be a strong indicator for assessing the hepatic inflammatory degree and used for antiviral treatment decisions in CHB patients with normal ALT levels.Jiyuan ZhouLiuwei SongHong ZhaoLinlin YanAnlin MaShibin XieXuqing ZhangDazhi ZhangQing XieGuo ZhangJia ShangJun ChengWeifeng ZhaoZhiqiang ZouMingxiang ZhangNingshao XiaGuiqiang WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Jiyuan Zhou Liuwei Song Hong Zhao Linlin Yan Anlin Ma Shibin Xie Xuqing Zhang Dazhi Zhang Qing Xie Guo Zhang Jia Shang Jun Cheng Weifeng Zhao Zhiqiang Zou Mingxiang Zhang Ningshao Xia Guiqiang Wang Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase |
| description |
Abstract Our previous studies unexpectedly indicated that the level of serum hepatitis B core antibody (anti-HBc) was positively correlated with the serum alanine aminotransferase (ALT) level. The aim of this study was to determine whether anti-HBc could serve as a potential biomarker for the detection of liver inflammation in chronic hepatitis B (CHB) patients, especially in patients with normal ALT levels. Serum anti-HBc levels were quantified in 655 treatment-naïve CHB patients, including 45 patients who underwent two liver biopsies (baseline phase and the 78th weeks of antiviral-treatment). Serum anti-HBc levels increased significantly along with the increasing histology activity index (HAI) score. After antiviral-treatment, patients with HAI score reduction had significant decline in serum anti-HBc level. Multivariate analysis showed that anti-HBc was independently associated with moderate-to-severe hepatic inflammation in patients with normal ALT level. Furthermore, serum anti-HBc showed a high diagnostic accuracy for predicting moderate-to-severe inflammation in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative CHB patients with normal ALT levels (area under the curve, AUC = 0.87 and 0.75; respectively). Thus, anti-HBc may be a strong indicator for assessing the hepatic inflammatory degree and used for antiviral treatment decisions in CHB patients with normal ALT levels. |
| format |
article |
| author |
Jiyuan Zhou Liuwei Song Hong Zhao Linlin Yan Anlin Ma Shibin Xie Xuqing Zhang Dazhi Zhang Qing Xie Guo Zhang Jia Shang Jun Cheng Weifeng Zhao Zhiqiang Zou Mingxiang Zhang Ningshao Xia Guiqiang Wang |
| author_facet |
Jiyuan Zhou Liuwei Song Hong Zhao Linlin Yan Anlin Ma Shibin Xie Xuqing Zhang Dazhi Zhang Qing Xie Guo Zhang Jia Shang Jun Cheng Weifeng Zhao Zhiqiang Zou Mingxiang Zhang Ningshao Xia Guiqiang Wang |
| author_sort |
Jiyuan Zhou |
| title |
Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase |
| title_short |
Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase |
| title_full |
Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase |
| title_fullStr |
Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase |
| title_full_unstemmed |
Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase |
| title_sort |
serum hepatitis b core antibody as a biomarker of hepatic inflammation in chronic hepatitis b patients with normal alanine aminotransferase |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e8c68542a267458287b8868a1a7e39f3 |
| work_keys_str_mv |
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