Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

Cisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across different mice organs following platinum treatment.

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Autores principales:	Askar Yimit, Ogun Adebali, Aziz Sancar, Yuchao Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8c9077bcabd4f6dbd5440dc994c0977
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spelling	oai:doaj.org-article:e8c9077bcabd4f6dbd5440dc994c09772021-12-02T14:39:36ZDifferential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs10.1038/s41467-019-08290-22041-1723https://doaj.org/article/e8c9077bcabd4f6dbd5440dc994c09772019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08290-2https://doaj.org/toc/2041-1723Cisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across different mice organs following platinum treatment.Askar YimitOgun AdebaliAziz SancarYuchao JiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Askar Yimit Ogun Adebali Aziz Sancar Yuchao Jiang Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
description	Cisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across different mice organs following platinum treatment.
format	article
author	Askar Yimit Ogun Adebali Aziz Sancar Yuchao Jiang
author_facet	Askar Yimit Ogun Adebali Aziz Sancar Yuchao Jiang
author_sort	Askar Yimit
title	Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_short	Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_full	Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_fullStr	Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_full_unstemmed	Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_sort	differential damage and repair of dna-adducts induced by anti-cancer drug cisplatin across mouse organs
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e8c9077bcabd4f6dbd5440dc994c0977
work_keys_str_mv	AT askaryimit differentialdamageandrepairofdnaadductsinducedbyanticancerdrugcisplatinacrossmouseorgans AT ogunadebali differentialdamageandrepairofdnaadductsinducedbyanticancerdrugcisplatinacrossmouseorgans AT azizsancar differentialdamageandrepairofdnaadductsinducedbyanticancerdrugcisplatinacrossmouseorgans AT yuchaojiang differentialdamageandrepairofdnaadductsinducedbyanticancerdrugcisplatinacrossmouseorgans
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Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

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