A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin
Tuberculosis (TB) subunit vaccines have been investigated as boosters for BCG-induced immunity. Here, the authors design a TB subunit vaccine that doesn't share antigens with BCG and show that co-administration of the two vaccines broadens the T cell response to TB and increases protection.
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Nature Portfolio
2021
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oai:doaj.org-article:e8cde506edf04ab4beac2a4d5130dcb72021-11-21T12:35:17ZA Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin10.1038/s41467-021-26934-02041-1723https://doaj.org/article/e8cde506edf04ab4beac2a4d5130dcb72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26934-0https://doaj.org/toc/2041-1723Tuberculosis (TB) subunit vaccines have been investigated as boosters for BCG-induced immunity. Here, the authors design a TB subunit vaccine that doesn't share antigens with BCG and show that co-administration of the two vaccines broadens the T cell response to TB and increases protection.Joshua S. WoodworthHelena Strand ClemmensenHannah BatteyKarin DijkmanThomas LindenstrømRaquel Salvador LaureanoRandy TaplitzJeffrey MorganClaus AagaardIda RosenkrandsCecilia S. Lindestam ArlehamnPeter AndersenRasmus MortensenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Joshua S. Woodworth Helena Strand Clemmensen Hannah Battey Karin Dijkman Thomas Lindenstrøm Raquel Salvador Laureano Randy Taplitz Jeffrey Morgan Claus Aagaard Ida Rosenkrands Cecilia S. Lindestam Arlehamn Peter Andersen Rasmus Mortensen A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin |
| description |
Tuberculosis (TB) subunit vaccines have been investigated as boosters for BCG-induced immunity. Here, the authors design a TB subunit vaccine that doesn't share antigens with BCG and show that co-administration of the two vaccines broadens the T cell response to TB and increases protection. |
| format |
article |
| author |
Joshua S. Woodworth Helena Strand Clemmensen Hannah Battey Karin Dijkman Thomas Lindenstrøm Raquel Salvador Laureano Randy Taplitz Jeffrey Morgan Claus Aagaard Ida Rosenkrands Cecilia S. Lindestam Arlehamn Peter Andersen Rasmus Mortensen |
| author_facet |
Joshua S. Woodworth Helena Strand Clemmensen Hannah Battey Karin Dijkman Thomas Lindenstrøm Raquel Salvador Laureano Randy Taplitz Jeffrey Morgan Claus Aagaard Ida Rosenkrands Cecilia S. Lindestam Arlehamn Peter Andersen Rasmus Mortensen |
| author_sort |
Joshua S. Woodworth |
| title |
A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin |
| title_short |
A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin |
| title_full |
A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin |
| title_fullStr |
A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin |
| title_full_unstemmed |
A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin |
| title_sort |
mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with bacillus calmette-guérin |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e8cde506edf04ab4beac2a4d5130dcb7 |
| work_keys_str_mv |
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