Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis

Cervical cancer, as the second most common female malignancy, brings a great health burden to women worldwide. Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the most common histological subtypes of cervical cancer. CXC chemokines (CXCLs) within the tumor microenvironmen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Caiyun Wu, Cong Ma, Jing Yuan, Pei Zhou
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	bioinformatics cxc chemokines cervical squamous cell carcinoma and endocervical adenocarcinoma therapy prognosis Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/e8ceea7e486b4530828685630519d882
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e8ceea7e486b4530828685630519d882
record_format	dspace
spelling	oai:doaj.org-article:e8ceea7e486b4530828685630519d8822021-11-24T01:04:46ZExploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis10.3934/mbe.20214071551-0018https://doaj.org/article/e8ceea7e486b4530828685630519d8822021-09-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021407?viewType=HTMLhttps://doaj.org/toc/1551-0018Cervical cancer, as the second most common female malignancy, brings a great health burden to women worldwide. Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the most common histological subtypes of cervical cancer. CXC chemokines (CXCLs) within the tumor microenvironment can modulate carcinogenesis and progression. The present study aimed to explore the therapeutic and prognostic value of different CXCLs in CESC. ONCOMINE, GEPIA, cBioPortal, TRRUST, GeneMANIA, STRING and TIMER were utilized to explore the expression, mutation and function of CXCLs in CESC, as well as their correlation with pathological and survival features of CESC patients. We found that the mRNA expression levels of CXCL1/8/9/10/11/13/16/17 in CESC were upregulated compared with normal cervical tissues, whereas CXCL12 was downregulated. No significant correlation was found between the expression levels and pathological stage of CESC patients. CESC patients with high expression of CXCL1/2/3/4/5/8 were significantly associated with poor overall survival, additionally, low mRNA level of CXCL3 was associated with better disease-free survival. Besides, a high mutation rate (43%) of CXCLs in CESC was observed. Depicted by co-expression analysis, the expression of CXCL1/2/3/6/8 showed a modest to strong correlation, while that of CXCL9/10/11/13 showed a very strong correlation. Differentially expressed CXCLs primarily functioned in chemokine signaling pathway and inflammation response, such as cell chemotaxis, chemokine activity and chemokine receptor binding. We also found the association of CXCLs with the tumor-infiltration of six types of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells) in CESC patients. The present study elucidated that CXCLs may have the potential to be novel therapeutic targets and prognosis predictors of CESC patients.Caiyun WuCong MaJing YuanPei ZhouAIMS Pressarticlebioinformaticscxc chemokinescervical squamous cell carcinoma and endocervical adenocarcinomatherapyprognosisBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 8201-8222 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioinformatics cxc chemokines cervical squamous cell carcinoma and endocervical adenocarcinoma therapy prognosis Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	bioinformatics cxc chemokines cervical squamous cell carcinoma and endocervical adenocarcinoma therapy prognosis Biotechnology TP248.13-248.65 Mathematics QA1-939 Caiyun Wu Cong Ma Jing Yuan Pei Zhou Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis
description	Cervical cancer, as the second most common female malignancy, brings a great health burden to women worldwide. Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the most common histological subtypes of cervical cancer. CXC chemokines (CXCLs) within the tumor microenvironment can modulate carcinogenesis and progression. The present study aimed to explore the therapeutic and prognostic value of different CXCLs in CESC. ONCOMINE, GEPIA, cBioPortal, TRRUST, GeneMANIA, STRING and TIMER were utilized to explore the expression, mutation and function of CXCLs in CESC, as well as their correlation with pathological and survival features of CESC patients. We found that the mRNA expression levels of CXCL1/8/9/10/11/13/16/17 in CESC were upregulated compared with normal cervical tissues, whereas CXCL12 was downregulated. No significant correlation was found between the expression levels and pathological stage of CESC patients. CESC patients with high expression of CXCL1/2/3/4/5/8 were significantly associated with poor overall survival, additionally, low mRNA level of CXCL3 was associated with better disease-free survival. Besides, a high mutation rate (43%) of CXCLs in CESC was observed. Depicted by co-expression analysis, the expression of CXCL1/2/3/6/8 showed a modest to strong correlation, while that of CXCL9/10/11/13 showed a very strong correlation. Differentially expressed CXCLs primarily functioned in chemokine signaling pathway and inflammation response, such as cell chemotaxis, chemokine activity and chemokine receptor binding. We also found the association of CXCLs with the tumor-infiltration of six types of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells) in CESC patients. The present study elucidated that CXCLs may have the potential to be novel therapeutic targets and prognosis predictors of CESC patients.
format	article
author	Caiyun Wu Cong Ma Jing Yuan Pei Zhou
author_facet	Caiyun Wu Cong Ma Jing Yuan Pei Zhou
author_sort	Caiyun Wu
title	Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis
title_short	Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis
title_full	Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis
title_fullStr	Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis
title_full_unstemmed	Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis
title_sort	exploration of potential therapeutic and prognostic value of cxc chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/e8ceea7e486b4530828685630519d882
work_keys_str_mv	AT caiyunwu explorationofpotentialtherapeuticandprognosticvalueofcxcchemokinesincervicalsquamouscellcarcinomaandendocervicaladenocarcinomabasedonbioinformaticsanalysis AT congma explorationofpotentialtherapeuticandprognosticvalueofcxcchemokinesincervicalsquamouscellcarcinomaandendocervicaladenocarcinomabasedonbioinformaticsanalysis AT jingyuan explorationofpotentialtherapeuticandprognosticvalueofcxcchemokinesincervicalsquamouscellcarcinomaandendocervicaladenocarcinomabasedonbioinformaticsanalysis AT peizhou explorationofpotentialtherapeuticandprognosticvalueofcxcchemokinesincervicalsquamouscellcarcinomaandendocervicaladenocarcinomabasedonbioinformaticsanalysis
_version_	1718416067260317696

Exploration of potential therapeutic and prognostic value of CXC chemokines in cervical squamous cell carcinoma and endocervical adenocarcinoma based on bioinformatics analysis

Ejemplares similares