Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort

Background/Aims This study was performed to clarify inf luences of anticentromere antibody (ACA) on clinical phenotypes of primary Sjögren’s syndrome (pSS) patients in Korea. Methods We assessed 318 patients who met the 2016 American College of Rheumatology/ European League Against Rheumatism classi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Youngjae Park, Jennifer Lee, Jung Hee Koh, Jung Yoon Choe, Yoon-Kyoung Sung, Shin-Seok Lee, Ji-Min Kim, Sung-Hwan Park, Seung-Ki Kwok
Formato:	article
Lenguaje:	EN
Publicado:	The Korean Association of Internal Medicine 2021
Materias:	sjogren’s syndrome anticentromere antibody phenotype Medicine R
Acceso en línea:	https://doaj.org/article/e8d0e8e78dfb4815a1e84a31c398ea14
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e8d0e8e78dfb4815a1e84a31c398ea14
record_format	dspace
spelling	oai:doaj.org-article:e8d0e8e78dfb4815a1e84a31c398ea142021-11-08T00:59:06ZClinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort1226-33032005-664810.3904/kjim.2020.146https://doaj.org/article/e8d0e8e78dfb4815a1e84a31c398ea142021-11-01T00:00:00Zhttp://www.kjim.org/upload/pdf/kjim-2020-146.pdfhttps://doaj.org/toc/1226-3303https://doaj.org/toc/2005-6648Background/Aims This study was performed to clarify inf luences of anticentromere antibody (ACA) on clinical phenotypes of primary Sjögren’s syndrome (pSS) patients in Korea. Methods We assessed 318 patients who met the 2016 American College of Rheumatology/ European League Against Rheumatism classification criteria for pSS. All patients were selected from the Korean Initiative of primary Sjögren’s Syndrome (KISS), a prospective cohort. Among them, 53 patients were positive for ACA, while another 265 patients were not. We compared various clinical data including demographic features, extra-glandular manifestations (EGMs), clinical indices, and laboratory values available from the KISS database between the two groups. Results Patients in the ACA-positive pSS group were older (p = 0.042), and had higher xerostomia inventory scores (p = 0.040), whereas glandular dysfunction represented with Schirmer I test was more severe in the ACA-negative group. More frequent Raynaud’s phenomenon and liver involvement (both p < 0.001) and less articular involvement (p = 0.037) were observed among the EGMs in the ACA-positive group. Less frequency of leukopenia (p = 0.021), rheumatoid factor (p < 0.001), anti-Ro/SSA antibody positivity (p < 0.001), and hypergammaglobulinemia (p = 0.006), as well as higher positivity rates of anti-nuclear antibody and anti- topoisomerase antibody (p < 0.001 and p = 0.006, respectively) were found in the laboratory data in the ACA-positive pSS group. Conclusions Considering distinct phenotypes in hematological and serological features and EGMs, we should monitor the occurrence of these clinical features among pSS patients with ACA in caution.Youngjae ParkJennifer LeeJung Hee KohJung Yoon ChoeYoon-Kyoung SungShin-Seok LeeJi-Min KimSung-Hwan ParkSeung-Ki KwokThe Korean Association of Internal Medicinearticlesjogren’s syndromeanticentromere antibodyphenotypeMedicineRENThe Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1492-1503 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sjogren’s syndrome anticentromere antibody phenotype Medicine R
spellingShingle	sjogren’s syndrome anticentromere antibody phenotype Medicine R Youngjae Park Jennifer Lee Jung Hee Koh Jung Yoon Choe Yoon-Kyoung Sung Shin-Seok Lee Ji-Min Kim Sung-Hwan Park Seung-Ki Kwok Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
description	Background/Aims This study was performed to clarify inf luences of anticentromere antibody (ACA) on clinical phenotypes of primary Sjögren’s syndrome (pSS) patients in Korea. Methods We assessed 318 patients who met the 2016 American College of Rheumatology/ European League Against Rheumatism classification criteria for pSS. All patients were selected from the Korean Initiative of primary Sjögren’s Syndrome (KISS), a prospective cohort. Among them, 53 patients were positive for ACA, while another 265 patients were not. We compared various clinical data including demographic features, extra-glandular manifestations (EGMs), clinical indices, and laboratory values available from the KISS database between the two groups. Results Patients in the ACA-positive pSS group were older (p = 0.042), and had higher xerostomia inventory scores (p = 0.040), whereas glandular dysfunction represented with Schirmer I test was more severe in the ACA-negative group. More frequent Raynaud’s phenomenon and liver involvement (both p < 0.001) and less articular involvement (p = 0.037) were observed among the EGMs in the ACA-positive group. Less frequency of leukopenia (p = 0.021), rheumatoid factor (p < 0.001), anti-Ro/SSA antibody positivity (p < 0.001), and hypergammaglobulinemia (p = 0.006), as well as higher positivity rates of anti-nuclear antibody and anti- topoisomerase antibody (p < 0.001 and p = 0.006, respectively) were found in the laboratory data in the ACA-positive pSS group. Conclusions Considering distinct phenotypes in hematological and serological features and EGMs, we should monitor the occurrence of these clinical features among pSS patients with ACA in caution.
format	article
author	Youngjae Park Jennifer Lee Jung Hee Koh Jung Yoon Choe Yoon-Kyoung Sung Shin-Seok Lee Ji-Min Kim Sung-Hwan Park Seung-Ki Kwok
author_facet	Youngjae Park Jennifer Lee Jung Hee Koh Jung Yoon Choe Yoon-Kyoung Sung Shin-Seok Lee Ji-Min Kim Sung-Hwan Park Seung-Ki Kwok
author_sort	Youngjae Park
title	Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
title_short	Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
title_full	Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
title_fullStr	Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
title_full_unstemmed	Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
title_sort	clinical influences of anticentromere antibody on primary sjögren’s syndrome in a prospective korean cohort
publisher	The Korean Association of Internal Medicine
publishDate	2021
url	https://doaj.org/article/e8d0e8e78dfb4815a1e84a31c398ea14
work_keys_str_mv	AT youngjaepark clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT jenniferlee clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT jungheekoh clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT jungyoonchoe clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT yoonkyoungsung clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT shinseoklee clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT jiminkim clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT sunghwanpark clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort AT seungkikwok clinicalinfluencesofanticentromereantibodyonprimarysjogrenssyndromeinaprospectivekoreancohort
_version_	1718443322804011008

Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort

Ejemplares similares