Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials

The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. Here, Morvan et al. show that exogenous fatty acids can favour the emergence of staphylococcal strains displaying resistance to multiple FASII inhibitors.

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Autores principales:	Claire Morvan, David Halpern, Gérald Kénanian, Constantin Hays, Jamila Anba-Mondoloni, Sophie Brinster, Sean Kennedy, Patrick Trieu-Cuot, Claire Poyart, Gilles Lamberet, Karine Gloux, Alexandra Gruss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8d21997597244098908c235c4491102
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spelling	oai:doaj.org-article:e8d21997597244098908c235c44911022021-12-02T16:57:28ZEnvironmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials10.1038/ncomms129442041-1723https://doaj.org/article/e8d21997597244098908c235c44911022016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12944https://doaj.org/toc/2041-1723The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. Here, Morvan et al. show that exogenous fatty acids can favour the emergence of staphylococcal strains displaying resistance to multiple FASII inhibitors.Claire MorvanDavid HalpernGérald KénanianConstantin HaysJamila Anba-MondoloniSophie BrinsterSean KennedyPatrick Trieu-CuotClaire PoyartGilles LamberetKarine GlouxAlexandra GrussNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claire Morvan David Halpern Gérald Kénanian Constantin Hays Jamila Anba-Mondoloni Sophie Brinster Sean Kennedy Patrick Trieu-Cuot Claire Poyart Gilles Lamberet Karine Gloux Alexandra Gruss Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials
description	The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. Here, Morvan et al. show that exogenous fatty acids can favour the emergence of staphylococcal strains displaying resistance to multiple FASII inhibitors.
format	article
author	Claire Morvan David Halpern Gérald Kénanian Constantin Hays Jamila Anba-Mondoloni Sophie Brinster Sean Kennedy Patrick Trieu-Cuot Claire Poyart Gilles Lamberet Karine Gloux Alexandra Gruss
author_facet	Claire Morvan David Halpern Gérald Kénanian Constantin Hays Jamila Anba-Mondoloni Sophie Brinster Sean Kennedy Patrick Trieu-Cuot Claire Poyart Gilles Lamberet Karine Gloux Alexandra Gruss
author_sort	Claire Morvan
title	Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials
title_short	Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials
title_full	Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials
title_fullStr	Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials
title_full_unstemmed	Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials
title_sort	environmental fatty acids enable emergence of infectious staphylococcus aureus resistant to fasii-targeted antimicrobials
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e8d21997597244098908c235c4491102
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Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials

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