Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species

Wenqi Luo,1,2 Yiming Wang,1,2 Feng Lin,1,2 Yixuan Liu,2,3 Rui Gu,1 Wanguo Liu,1 Chunsheng Xiao2,4 1Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China; 2Key Laboratory of Polymer Ecomaterials, Changchun Institute o...

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Autores principales:	Luo W, Wang Y, Lin F, Liu Y, Gu R, Liu W, Xiao C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	carbon quantum dots spinal cord injury reactive oxygen species antioxidant inflammation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e8d327010fec4b89af24aa656d091e47
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spelling	oai:doaj.org-article:e8d327010fec4b89af24aa656d091e472021-12-02T10:39:30ZSelenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species1178-2013https://doaj.org/article/e8d327010fec4b89af24aa656d091e472020-12-01T00:00:00Zhttps://www.dovepress.com/selenium-doped-carbon-quantum-dots-efficiently-ameliorate-secondary-sp-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Wenqi Luo,1,2 Yiming Wang,1,2 Feng Lin,1,2 Yixuan Liu,2,3 Rui Gu,1 Wanguo Liu,1 Chunsheng Xiao2,4 1Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China; 2Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China; 3School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, People’s Republic of China; 4Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, People’s Republic of ChinaCorrespondence: Wanguo Liu; Rui Gu Email liuwanguo6016@jlu.edu.cn; gurui@jlu.edu.cnBackground: The excess production of reactive oxygen species (ROS) after traumatic spinal cord injury (TSCI) has been identified as a leading cause of secondary injury, which can significantly exacerbate acute damage in the injured spinal cord. Thus, scavenging of ROS has emerged as an effective route to ameliorate secondary spinal cord injury.Purpose: Selenium-doped carbon quantum dots (Se-CQDs) with the ability to scavenge reactive oxygen species were prepared and used for efficiently ameliorating secondary injury in TSCI.Methods: Water-soluble Se-CQDs were easily synthesized via hydrothermal treatment of l-selenocystine. The chemical structure, size, and morphology of the Se-CQDs were characterized in detail. The biocompatibility and protective effects of the Se-CQDs against H2O2-induced oxidative damage were investigated in vitro. Moreover, the behavioral test, bladder function, histological observation, Western blot were used to investigate the neuroprotective effect of Se-CQDs in a rat model of contusion TSCI.Results: The obtained Se-CQDs exhibited good biocompatibility and remarkable protective effect against H2O2-induced oxidative damage in astrocytes and PC12 cells. Moreover, Se-CQDs displayed marked anti-inﬂammatory and anti-apoptotic activities, which thereby reduced the formation of glial scars and increased the survival of neurons with unscathed myelin sheaths in vivo. As a result, Se-CQDs were capable of largely improving locomotor function of rats with TSCI.Conclusion: This study suggests that Se-CQDs can be used as a promising therapeutic platform for ameliorating secondary injury in TSCI.Keywords: carbon quantum dots, spinal cord injury, reactive oxygen species, antioxidant, inflammationLuo WWang YLin FLiu YGu RLiu WXiao CDove Medical Pressarticlecarbon quantum dotsspinal cord injuryreactive oxygen speciesantioxidantinflammationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 10113-10125 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon quantum dots spinal cord injury reactive oxygen species antioxidant inflammation Medicine (General) R5-920
spellingShingle	carbon quantum dots spinal cord injury reactive oxygen species antioxidant inflammation Medicine (General) R5-920 Luo W Wang Y Lin F Liu Y Gu R Liu W Xiao C Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species
description	Wenqi Luo,1,2 Yiming Wang,1,2 Feng Lin,1,2 Yixuan Liu,2,3 Rui Gu,1 Wanguo Liu,1 Chunsheng Xiao2,4 1Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China; 2Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China; 3School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, People’s Republic of China; 4Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, People’s Republic of ChinaCorrespondence: Wanguo Liu; Rui Gu Email liuwanguo6016@jlu.edu.cn; gurui@jlu.edu.cnBackground: The excess production of reactive oxygen species (ROS) after traumatic spinal cord injury (TSCI) has been identified as a leading cause of secondary injury, which can significantly exacerbate acute damage in the injured spinal cord. Thus, scavenging of ROS has emerged as an effective route to ameliorate secondary spinal cord injury.Purpose: Selenium-doped carbon quantum dots (Se-CQDs) with the ability to scavenge reactive oxygen species were prepared and used for efficiently ameliorating secondary injury in TSCI.Methods: Water-soluble Se-CQDs were easily synthesized via hydrothermal treatment of l-selenocystine. The chemical structure, size, and morphology of the Se-CQDs were characterized in detail. The biocompatibility and protective effects of the Se-CQDs against H2O2-induced oxidative damage were investigated in vitro. Moreover, the behavioral test, bladder function, histological observation, Western blot were used to investigate the neuroprotective effect of Se-CQDs in a rat model of contusion TSCI.Results: The obtained Se-CQDs exhibited good biocompatibility and remarkable protective effect against H2O2-induced oxidative damage in astrocytes and PC12 cells. Moreover, Se-CQDs displayed marked anti-inﬂammatory and anti-apoptotic activities, which thereby reduced the formation of glial scars and increased the survival of neurons with unscathed myelin sheaths in vivo. As a result, Se-CQDs were capable of largely improving locomotor function of rats with TSCI.Conclusion: This study suggests that Se-CQDs can be used as a promising therapeutic platform for ameliorating secondary injury in TSCI.Keywords: carbon quantum dots, spinal cord injury, reactive oxygen species, antioxidant, inflammation
format	article
author	Luo W Wang Y Lin F Liu Y Gu R Liu W Xiao C
author_facet	Luo W Wang Y Lin F Liu Y Gu R Liu W Xiao C
author_sort	Luo W
title	Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species
title_short	Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species
title_full	Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species
title_fullStr	Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species
title_full_unstemmed	Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species
title_sort	selenium-doped carbon quantum dots efficiently ameliorate secondary spinal cord injury via scavenging reactive oxygen species
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e8d327010fec4b89af24aa656d091e47
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Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species

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