LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS

Oxidative stress is an acknowledged pathogenic mechanism in Type 1 diabetes mellitus. Acute increases in plasma glucose concentration may increase free radical production by the following mechanisms: labile glycation; auto-oxidation of glucose, and intracellular activation of the polyol pathway; whi...

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Autores principales:	L. I. Kolesnikova, M. A. Darenskaya, L. A. Grebenkina, T. P. Bardymova, S. V. Gnusina, N. V. Semenova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	type 1 diabetes lipid peroxidation ethnic group Science Q
Acceso en línea:	https://doaj.org/article/e8d77de90da74a8f96ea6c123324dae8
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spelling	oai:doaj.org-article:e8d77de90da74a8f96ea6c123324dae82021-11-23T06:14:28ZLIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS2541-94202587-9596https://doaj.org/article/e8d77de90da74a8f96ea6c123324dae82013-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1618https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Oxidative stress is an acknowledged pathogenic mechanism in Type 1 diabetes mellitus. Acute increases in plasma glucose concentration may increase free radical production by the following mechanisms: labile glycation; auto-oxidation of glucose, and intracellular activation of the polyol pathway; which produces an imbalance in the NADh/NAD+ ratio and favours the production of free radicals. Incidence, severity, and rate of complications of Type 1 diabetes mellitus are associated with many factors including geographic location and ethnicity. The main features of lipid peroxidation in 30 women with type 1 diabetes in Buryat and Russian ethnic groups were examined. The materials for biochemical studies were blood serum and red cells. The content of the substrates and products of lipid peroxidation (diene conjugates, ketodienes and coupled trienes, malondialdehyde), total antioxidant activity of serum and its components (superoxide dismutase, α-tocopherol, retinol, reduced and oxidized glutathione) were evaluated by a spectrofluorophotometer «SHIMADZU-1501» (Japan). Statistical analysis was performed by non-parametric tests. It is shown that the intensity of lipid peroxidation processes in patients Buryat ethnic group is reduced in comparison with Russian ethnic group, that confirmed by the values of the coefficient of oxidative stress. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7).L. I. KolesnikovaM. A. DarenskayaL. A. GrebenkinaT. P. BardymovaS. V. GnusinaN. V. SemenovaScientific Сentre for Family Health and Human Reproduction Problemsarticletype 1 diabeteslipid peroxidationethnic groupScienceQRUActa Biomedica Scientifica, Vol 0, Iss 4, Pp 131-135 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	type 1 diabetes lipid peroxidation ethnic group Science Q
spellingShingle	type 1 diabetes lipid peroxidation ethnic group Science Q L. I. Kolesnikova M. A. Darenskaya L. A. Grebenkina T. P. Bardymova S. V. Gnusina N. V. Semenova LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS
description	Oxidative stress is an acknowledged pathogenic mechanism in Type 1 diabetes mellitus. Acute increases in plasma glucose concentration may increase free radical production by the following mechanisms: labile glycation; auto-oxidation of glucose, and intracellular activation of the polyol pathway; which produces an imbalance in the NADh/NAD+ ratio and favours the production of free radicals. Incidence, severity, and rate of complications of Type 1 diabetes mellitus are associated with many factors including geographic location and ethnicity. The main features of lipid peroxidation in 30 women with type 1 diabetes in Buryat and Russian ethnic groups were examined. The materials for biochemical studies were blood serum and red cells. The content of the substrates and products of lipid peroxidation (diene conjugates, ketodienes and coupled trienes, malondialdehyde), total antioxidant activity of serum and its components (superoxide dismutase, α-tocopherol, retinol, reduced and oxidized glutathione) were evaluated by a spectrofluorophotometer «SHIMADZU-1501» (Japan). Statistical analysis was performed by non-parametric tests. It is shown that the intensity of lipid peroxidation processes in patients Buryat ethnic group is reduced in comparison with Russian ethnic group, that confirmed by the values of the coefficient of oxidative stress. The study was supported by grants of the President of the Council of the Russian Federation (Scientific School 494.2012.7).
format	article
author	L. I. Kolesnikova M. A. Darenskaya L. A. Grebenkina T. P. Bardymova S. V. Gnusina N. V. Semenova
author_facet	L. I. Kolesnikova M. A. Darenskaya L. A. Grebenkina T. P. Bardymova S. V. Gnusina N. V. Semenova
author_sort	L. I. Kolesnikova
title	LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS
title_short	LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS
title_full	LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS
title_fullStr	LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS
title_full_unstemmed	LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS
title_sort	lipid peroxidation system in type 1 diabetes: ethnic aspects
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/e8d77de90da74a8f96ea6c123324dae8
work_keys_str_mv	AT likolesnikova lipidperoxidationsystemintype1diabetesethnicaspects AT madarenskaya lipidperoxidationsystemintype1diabetesethnicaspects AT lagrebenkina lipidperoxidationsystemintype1diabetesethnicaspects AT tpbardymova lipidperoxidationsystemintype1diabetesethnicaspects AT svgnusina lipidperoxidationsystemintype1diabetesethnicaspects AT nvsemenova lipidperoxidationsystemintype1diabetesethnicaspects
_version_	1718417168031285248

LIPID PEROXIDATION SYSTEM IN TYPE 1 DIABETES: ETHNIC ASPECTS

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