In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach

Transdermal delivery can be alternatively chosen for domperidone to improve its low oral bioavailability. The development of drugs into transdermal formulation needs information about the transport mechanism of the drug. This study aimed to develop models of domperidone transdermal transport in vitr...

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Autores principales:	Sekar Ayu Pawestri, Akhmad Kharis Nugroho, Endang Lukitaningsih
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	transdermal, domperidone, compartmental modeling, winsaam Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/e8d96236f36841ef8d3bb354df9035c9
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spelling	oai:doaj.org-article:e8d96236f36841ef8d3bb354df9035c92021-11-15T06:08:47ZIn vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach2338-94272338-948610.22146/ijp.608https://doaj.org/article/e8d96236f36841ef8d3bb354df9035c92021-01-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/608https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Transdermal delivery can be alternatively chosen for domperidone to improve its low oral bioavailability. The development of drugs into transdermal formulation needs information about the transport mechanism of the drug. This study aimed to develop models of domperidone transdermal transport in vitro based on compartmental modeling for understanding the domperidone transport mechanism. Domperidone solution (0.5g/L in a citric buffer, pH 5) was filled into the donor compartment. A comparative study was also conducted to examine the effect of different pH on domperidone transdermal transport in pH 1 (4g/L in 0.1M HCl). The shed snake-skin and cellophane membrane were pretreated for 1h with a chemical enhancer (oleic acid in propylene glycol) and assembled between the donor and the vertical diffusion cell's receptor compartment. The receptor compartment was filled in with phosphate-buffered saline at a pH of 6.8. The permeation study was performed for 8h. Samples concentration was assayed by UV-spectrophotometry. The cumulative permeation profiles of domperidone were analyzed using WinSAAM. Three and four-compartmental models were proposed with one lag compartment. The evaluation of the appropriate number of compartments in the transport model was examined based on the visual goodness of fit (GOF) and the corrected Akaike's information criterion (AICc) values. The four-compartmental model with one lag compartment was the best model describing percutaneous domperidone transport either in pH donor of 5 or pH 1. The model indicates domperidone transport follows into two parallel routes, including a lag compartment.Sekar Ayu PawestriAkhmad Kharis NugrohoEndang LukitaningsihUniversitas Gadjah Madaarticletransdermal, domperidone, compartmental modeling, winsaamPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 10-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transdermal, domperidone, compartmental modeling, winsaam Pharmacy and materia medica RS1-441
spellingShingle	transdermal, domperidone, compartmental modeling, winsaam Pharmacy and materia medica RS1-441 Sekar Ayu Pawestri Akhmad Kharis Nugroho Endang Lukitaningsih In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach
description	Transdermal delivery can be alternatively chosen for domperidone to improve its low oral bioavailability. The development of drugs into transdermal formulation needs information about the transport mechanism of the drug. This study aimed to develop models of domperidone transdermal transport in vitro based on compartmental modeling for understanding the domperidone transport mechanism. Domperidone solution (0.5g/L in a citric buffer, pH 5) was filled into the donor compartment. A comparative study was also conducted to examine the effect of different pH on domperidone transdermal transport in pH 1 (4g/L in 0.1M HCl). The shed snake-skin and cellophane membrane were pretreated for 1h with a chemical enhancer (oleic acid in propylene glycol) and assembled between the donor and the vertical diffusion cell's receptor compartment. The receptor compartment was filled in with phosphate-buffered saline at a pH of 6.8. The permeation study was performed for 8h. Samples concentration was assayed by UV-spectrophotometry. The cumulative permeation profiles of domperidone were analyzed using WinSAAM. Three and four-compartmental models were proposed with one lag compartment. The evaluation of the appropriate number of compartments in the transport model was examined based on the visual goodness of fit (GOF) and the corrected Akaike's information criterion (AICc) values. The four-compartmental model with one lag compartment was the best model describing percutaneous domperidone transport either in pH donor of 5 or pH 1. The model indicates domperidone transport follows into two parallel routes, including a lag compartment.
format	article
author	Sekar Ayu Pawestri Akhmad Kharis Nugroho Endang Lukitaningsih
author_facet	Sekar Ayu Pawestri Akhmad Kharis Nugroho Endang Lukitaningsih
author_sort	Sekar Ayu Pawestri
title	In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach
title_short	In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach
title_full	In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach
title_fullStr	In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach
title_full_unstemmed	In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach
title_sort	in vitro transdermal transport of domperidone by compartmental modeling approach
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/e8d96236f36841ef8d3bb354df9035c9
work_keys_str_mv	AT sekarayupawestri invitrotransdermaltransportofdomperidonebycompartmentalmodelingapproach AT akhmadkharisnugroho invitrotransdermaltransportofdomperidonebycompartmentalmodelingapproach AT endanglukitaningsih invitrotransdermaltransportofdomperidonebycompartmentalmodelingapproach
_version_	1718428589852983296

In vitro Transdermal Transport of Domperidone by Compartmental Modeling Approach

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