The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study

Zohreh Esfandiar,1 Firoozeh Hosseini-Esfahani,1 Parvin Mirmiran,1 Emad Yuzbashian,1 Fereidoun Azizi2 1Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Endocrine Research Center, Research Institute for E...

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Autores principales:	Esfandiar Z, Hosseini-Esfahani F, Mirmiran P, Yuzbashian E, Azizi F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	polyphenols flavonoids phenolic acids stilbenes lignans diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e8dedc8d034943458aa189c483e2acf3
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spelling	oai:doaj.org-article:e8dedc8d034943458aa189c483e2acf32021-12-02T12:08:17ZThe Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study1178-7007https://doaj.org/article/e8dedc8d034943458aa189c483e2acf32020-05-01T00:00:00Zhttps://www.dovepress.com/the-association-of-dietary-polyphenol-intake-with-the-risk-of-type-2-d-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Zohreh Esfandiar,1 Firoozeh Hosseini-Esfahani,1 Parvin Mirmiran,1 Emad Yuzbashian,1 Fereidoun Azizi2 1Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranCorrespondence: Parvin MirmiranNutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranTel +98 21 22432500Fax +98 21 22402463Email mirmiran@endocrine.ac.irFiroozeh Hosseini-EsfahaniNutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEmail f.hosseini@sbmu.ac.irPurpose: The current study aimed to investigate the relationship between daily consumption of total polyphenol and its subclasses and the incidence of diabetes.Materials and Methods: Eligible adults (n=6,547) were chosen from among participants of the Tehran Lipid and Glucose Study (TLGS) with an average follow-up of 3.0± 1.6 years. Dietary intakes were evaluated using a valid and reliable semi-quantitative food frequency questionnaire. Biochemical variables and anthropometrics were evaluated at baseline and follow-up examinations. Multivariate Cox proportional hazard regression models were used to estimate the development of type 2 diabetes mellitus (T2DM) in relation to total intake of polyphenol and its subclasses (flavonoids, phenolic acids, stilbenes, and lignans).Results: This study was conducted on 2,882 men and 3,665 women, aged 41.3± 14.6 and 39.0± 13.4 years, respectively. The number of participants with the new-onset T2DM was 253. Mean intake of total polyphenol was 346± 245 mg/1000 kcal. Risk of type 2 diabetes decreased from quartiles 1 to 4 for total polyphenols (HR: 1.00, 0.37, 0.61, 0.50, Ptrend< 0.01), phenolic acids (HR: 1.00, 0.57, 0.49, 0.45, Ptrend< 0.01), and lignans (HR: 1.00, 0.67, 0.61, 0.60, Ptrend< 0.01), whereas non-significant results were found for flavonoids and stilbenes. This study suggests an inverse association between total intake of polyphenols, phenolic acids, and lignin, and the risk of T2DM.Conclusion: These results emphasize the potential protective role of polyphenol rich food groups (especially fruits and vegetables) in the prevention of T2DM.Keywords: polyphenols, flavonoids, phenolic acids, stilbenes, lignans, diabetesEsfandiar ZHosseini-Esfahani FMirmiran PYuzbashian EAzizi FDove Medical Pressarticlepolyphenolsflavonoidsphenolic acidsstilbeneslignansdiabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1643-1652 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyphenols flavonoids phenolic acids stilbenes lignans diabetes Specialties of internal medicine RC581-951
spellingShingle	polyphenols flavonoids phenolic acids stilbenes lignans diabetes Specialties of internal medicine RC581-951 Esfandiar Z Hosseini-Esfahani F Mirmiran P Yuzbashian E Azizi F The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study
description	Zohreh Esfandiar,1 Firoozeh Hosseini-Esfahani,1 Parvin Mirmiran,1 Emad Yuzbashian,1 Fereidoun Azizi2 1Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranCorrespondence: Parvin MirmiranNutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranTel +98 21 22432500Fax +98 21 22402463Email mirmiran@endocrine.ac.irFiroozeh Hosseini-EsfahaniNutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEmail f.hosseini@sbmu.ac.irPurpose: The current study aimed to investigate the relationship between daily consumption of total polyphenol and its subclasses and the incidence of diabetes.Materials and Methods: Eligible adults (n=6,547) were chosen from among participants of the Tehran Lipid and Glucose Study (TLGS) with an average follow-up of 3.0± 1.6 years. Dietary intakes were evaluated using a valid and reliable semi-quantitative food frequency questionnaire. Biochemical variables and anthropometrics were evaluated at baseline and follow-up examinations. Multivariate Cox proportional hazard regression models were used to estimate the development of type 2 diabetes mellitus (T2DM) in relation to total intake of polyphenol and its subclasses (flavonoids, phenolic acids, stilbenes, and lignans).Results: This study was conducted on 2,882 men and 3,665 women, aged 41.3± 14.6 and 39.0± 13.4 years, respectively. The number of participants with the new-onset T2DM was 253. Mean intake of total polyphenol was 346± 245 mg/1000 kcal. Risk of type 2 diabetes decreased from quartiles 1 to 4 for total polyphenols (HR: 1.00, 0.37, 0.61, 0.50, Ptrend< 0.01), phenolic acids (HR: 1.00, 0.57, 0.49, 0.45, Ptrend< 0.01), and lignans (HR: 1.00, 0.67, 0.61, 0.60, Ptrend< 0.01), whereas non-significant results were found for flavonoids and stilbenes. This study suggests an inverse association between total intake of polyphenols, phenolic acids, and lignin, and the risk of T2DM.Conclusion: These results emphasize the potential protective role of polyphenol rich food groups (especially fruits and vegetables) in the prevention of T2DM.Keywords: polyphenols, flavonoids, phenolic acids, stilbenes, lignans, diabetes
format	article
author	Esfandiar Z Hosseini-Esfahani F Mirmiran P Yuzbashian E Azizi F
author_facet	Esfandiar Z Hosseini-Esfahani F Mirmiran P Yuzbashian E Azizi F
author_sort	Esfandiar Z
title	The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study
title_short	The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study
title_full	The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study
title_fullStr	The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study
title_full_unstemmed	The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study
title_sort	association of dietary polyphenol intake with the risk of type 2 diabetes: tehran lipid and glucose study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e8dedc8d034943458aa189c483e2acf3
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The Association of Dietary Polyphenol Intake with the Risk of Type 2 Diabetes: Tehran Lipid and Glucose Study

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