ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS

Osteomyelitis of the lower jaw is one of the urgent problems of modern medicine. There are many reasons for the evolvement of purulent necrotic processes of the jaw bones, including the role of disorders in the systems of innate and adaptive immunity. The aim of the study was to determine the conten...

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Autores principales:	E. V. Paskova, E. V. Markelova, K. I. Shakhgeldyan, B. I. Geltser, A. B. Kriger
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	mandibular osteomyelitis serum cytokines tnfα il-17 il-4 prognostic value Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e8df14cb25454063bba2bd758353ff76
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spelling	oai:doaj.org-article:e8df14cb25454063bba2bd758353ff762021-11-18T08:03:48ZROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS1563-06252313-741X10.15789/1563-0625-2019-5-953-958https://doaj.org/article/e8df14cb25454063bba2bd758353ff762019-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1732https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOsteomyelitis of the lower jaw is one of the urgent problems of modern medicine. There are many reasons for the evolvement of purulent necrotic processes of the jaw bones, including the role of disorders in the systems of innate and adaptive immunity. The aim of the study was to determine the content of TNFα, IL-17, IL-4 in serum and mixed saliva in patients with uncomplicated mandibular fractures and posttraumatic osteomyelitis to determine the possibility of using these indicators for early diagnosis of posttraumatic complications. The article presents the results of a study of tumor necrosis factor α (TNFα), interleukin-17 (IL-17) and interleukin-4 (IL-4) cytokines in serum and mixed saliva in patients with uncomplicated mandibular fracture and post-traumatic osteomyelitis at the first and tenth days of observation. By means of single-layer neural networks, binary classifiers were built, allowing patients to be stratified by the clinical form of the disease and to predict its course. The probability of uncomplicated mandibular fracture is described by the ratio P = 1/(1+e-z), where the index z is determined by the level of TNFα, IL-17, and IL-4 at the first and tenth day of observation. The simulation confirmed high prognostic significance of serum TNFα and IL-17 for early verification of posttraumatic osteomyelitis, which was confirmed by the OTC and ROC indices, which varied from 87 to 100% in different models. Models 4 and 5, where TNFα recorded on the tenth day of the study was used as predictors, and a combination of TNFα and IL-17 obtained on the first day of hospitalization, were the most accurate. Modeling the results of the study of immunological indicators in the mixed saliva showed that the predictive properties have only IL-4 and IL-17, was on the tenth day of hospitalization that distinguishes these binary classifiers from similar indexes, derive from the levels of cytokines in blood serum. The results of the study indicate the important role of disorders in the system of рro- and anti-inflammatory cytokines in pathogenesis of post-traumatic osteomyelitis.E. V. PaskovaE. V. MarkelovaK. I. ShakhgeldyanB. I. GeltserA. B. KrigerSPb RAACIarticlemandibular osteomyelitisserum cytokinestnfαil-17il-4prognostic valueImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 5, Pp 953-958 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	mandibular osteomyelitis serum cytokines tnfα il-17 il-4 prognostic value Immunologic diseases. Allergy RC581-607
spellingShingle	mandibular osteomyelitis serum cytokines tnfα il-17 il-4 prognostic value Immunologic diseases. Allergy RC581-607 E. V. Paskova E. V. Markelova K. I. Shakhgeldyan B. I. Geltser A. B. Kriger ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS
description	Osteomyelitis of the lower jaw is one of the urgent problems of modern medicine. There are many reasons for the evolvement of purulent necrotic processes of the jaw bones, including the role of disorders in the systems of innate and adaptive immunity. The aim of the study was to determine the content of TNFα, IL-17, IL-4 in serum and mixed saliva in patients with uncomplicated mandibular fractures and posttraumatic osteomyelitis to determine the possibility of using these indicators for early diagnosis of posttraumatic complications. The article presents the results of a study of tumor necrosis factor α (TNFα), interleukin-17 (IL-17) and interleukin-4 (IL-4) cytokines in serum and mixed saliva in patients with uncomplicated mandibular fracture and post-traumatic osteomyelitis at the first and tenth days of observation. By means of single-layer neural networks, binary classifiers were built, allowing patients to be stratified by the clinical form of the disease and to predict its course. The probability of uncomplicated mandibular fracture is described by the ratio P = 1/(1+e-z), where the index z is determined by the level of TNFα, IL-17, and IL-4 at the first and tenth day of observation. The simulation confirmed high prognostic significance of serum TNFα and IL-17 for early verification of posttraumatic osteomyelitis, which was confirmed by the OTC and ROC indices, which varied from 87 to 100% in different models. Models 4 and 5, where TNFα recorded on the tenth day of the study was used as predictors, and a combination of TNFα and IL-17 obtained on the first day of hospitalization, were the most accurate. Modeling the results of the study of immunological indicators in the mixed saliva showed that the predictive properties have only IL-4 and IL-17, was on the tenth day of hospitalization that distinguishes these binary classifiers from similar indexes, derive from the levels of cytokines in blood serum. The results of the study indicate the important role of disorders in the system of рro- and anti-inflammatory cytokines in pathogenesis of post-traumatic osteomyelitis.
format	article
author	E. V. Paskova E. V. Markelova K. I. Shakhgeldyan B. I. Geltser A. B. Kriger
author_facet	E. V. Paskova E. V. Markelova K. I. Shakhgeldyan B. I. Geltser A. B. Kriger
author_sort	E. V. Paskova
title	ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS
title_short	ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS
title_full	ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS
title_fullStr	ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS
title_full_unstemmed	ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS
title_sort	role of cytokine-mediated mechanisms in development of post-traumatic mandibular osteomyelitis
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/e8df14cb25454063bba2bd758353ff76
work_keys_str_mv	AT evpaskova roleofcytokinemediatedmechanismsindevelopmentofposttraumaticmandibularosteomyelitis AT evmarkelova roleofcytokinemediatedmechanismsindevelopmentofposttraumaticmandibularosteomyelitis AT kishakhgeldyan roleofcytokinemediatedmechanismsindevelopmentofposttraumaticmandibularosteomyelitis AT bigeltser roleofcytokinemediatedmechanismsindevelopmentofposttraumaticmandibularosteomyelitis AT abkriger roleofcytokinemediatedmechanismsindevelopmentofposttraumaticmandibularosteomyelitis
_version_	1718422388360609792

ROLE OF CYTOKINE-MEDIATED MECHANISMS IN DEVELOPMENT OF POST-TRAUMATIC MANDIBULAR OSTEOMYELITIS

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