Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.

Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.

The Duffy (Fy) antigens act as receptors for chemokines as well as for Plasmodium vivax to invade human RBCs. A recent study has correlated the occurrence of the FY*A allele of Duffy gene with decreased susceptibility to vivax malaria, but no epidemiological correlation between the distribution of F...

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Autores principales: Anita Chittoria, Sujata Mohanty, Yogesh Kumar Jaiswal, Aparup Das
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Publicado: Public Library of Science (PLoS) 2012
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spelling oai:doaj.org-article:e8e0fa0f139049f5871f2c4d6bc1adbd2021-11-18T07:04:37ZNatural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.1932-620310.1371/journal.pone.0045219https://doaj.org/article/e8e0fa0f139049f5871f2c4d6bc1adbd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028857/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The Duffy (Fy) antigens act as receptors for chemokines as well as for Plasmodium vivax to invade human RBCs. A recent study has correlated the occurrence of the FY*A allele of Duffy gene with decreased susceptibility to vivax malaria, but no epidemiological correlation between the distribution of FY*A allele and incidences of vivax malaria has been established so far. Furthermore, if such correlations exist, whether natural selection has mediated the association, is an important question. Since India is highly endemic to P. vivax malaria with variable eco-climatic and varying vivax malaria epidemiology across different regions, such a question could well be answered in Indians. For this, we have genotyped the FY gene at the -33(rd) and the 125(th) nucleotide positions in 250 Indians sampled from six different zonal plus one tribal population covering the whole of India and studied possible correlations with eco-climatic and vivax malaria incidences. No FY*O allele was found, however, both the FY*A and FY*B alleles forming FY*A/FY*A, FY*A/FY*B and FY*B/FY*B genotypes were widely distributed among Indians. Five out of seven population samples significantly deviated from the Hardy-Weinberg equilibrium expectation, and two alleles (FY*A and FY*B) and the homozygote genotype, FY*B/FY*B were clinically distributed over the population coordinates. Furthermore, vivax malaria incidences over the past five years were significantly negatively and positively associated with the frequencies of the FY*A and FY*B alleles, respectively. The Northern Indians were highly differentiated from the other zonal population samples at the FY gene, as evidenced from the reconstructed Neighbor-Joining phylogenetic tree. The results specify the role of natural selection in the distribution of FY gene polymorphism in India. Furthermore, the hypotheses on the part of the FY*A allele in conferring protection to vivax malaria could be validated following population genetic studies in a vivax malaria epidemiological setting, such as India.Anita ChittoriaSujata MohantyYogesh Kumar JaiswalAparup DasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45219 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Anita Chittoria
Sujata Mohanty
Yogesh Kumar Jaiswal
Aparup Das
Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
description The Duffy (Fy) antigens act as receptors for chemokines as well as for Plasmodium vivax to invade human RBCs. A recent study has correlated the occurrence of the FY*A allele of Duffy gene with decreased susceptibility to vivax malaria, but no epidemiological correlation between the distribution of FY*A allele and incidences of vivax malaria has been established so far. Furthermore, if such correlations exist, whether natural selection has mediated the association, is an important question. Since India is highly endemic to P. vivax malaria with variable eco-climatic and varying vivax malaria epidemiology across different regions, such a question could well be answered in Indians. For this, we have genotyped the FY gene at the -33(rd) and the 125(th) nucleotide positions in 250 Indians sampled from six different zonal plus one tribal population covering the whole of India and studied possible correlations with eco-climatic and vivax malaria incidences. No FY*O allele was found, however, both the FY*A and FY*B alleles forming FY*A/FY*A, FY*A/FY*B and FY*B/FY*B genotypes were widely distributed among Indians. Five out of seven population samples significantly deviated from the Hardy-Weinberg equilibrium expectation, and two alleles (FY*A and FY*B) and the homozygote genotype, FY*B/FY*B were clinically distributed over the population coordinates. Furthermore, vivax malaria incidences over the past five years were significantly negatively and positively associated with the frequencies of the FY*A and FY*B alleles, respectively. The Northern Indians were highly differentiated from the other zonal population samples at the FY gene, as evidenced from the reconstructed Neighbor-Joining phylogenetic tree. The results specify the role of natural selection in the distribution of FY gene polymorphism in India. Furthermore, the hypotheses on the part of the FY*A allele in conferring protection to vivax malaria could be validated following population genetic studies in a vivax malaria epidemiological setting, such as India.
format article
author Anita Chittoria
Sujata Mohanty
Yogesh Kumar Jaiswal
Aparup Das
author_facet Anita Chittoria
Sujata Mohanty
Yogesh Kumar Jaiswal
Aparup Das
author_sort Anita Chittoria
title Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
title_short Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
title_full Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
title_fullStr Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
title_full_unstemmed Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
title_sort natural selection mediated association of the duffy (fy) gene polymorphisms with plasmodium vivax malaria in india.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/e8e0fa0f139049f5871f2c4d6bc1adbd
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AT yogeshkumarjaiswal naturalselectionmediatedassociationoftheduffyfygenepolymorphismswithplasmodiumvivaxmalariainindia
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