A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water

Metronidazole is an anti-parasitic drug of the nitro-5-imidazole class, discovered in 1959. The objective of this research was to construct a highly sensitive sensor to detect Metronidazole in real samples. We elaborated a carbon paste electrode modified with Al2O3 microparticles that are hydrotherm...

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Autores principales:	J. Zoubir, C. Radaa, A. Idlahcen, I. Bakas, A. Assabbane
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Electro-analysis Sensors Metronidazole Electrode µAl2O3@CPE Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5
Acceso en línea:	https://doaj.org/article/e8e215e7d92849bf99f5187145daab04
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spelling	oai:doaj.org-article:e8e215e7d92849bf99f5187145daab042021-11-30T04:17:10ZA new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water2589-299110.1016/j.mset.2021.08.003https://doaj.org/article/e8e215e7d92849bf99f5187145daab042021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589299121000306https://doaj.org/toc/2589-2991Metronidazole is an anti-parasitic drug of the nitro-5-imidazole class, discovered in 1959. The objective of this research was to construct a highly sensitive sensor to detect Metronidazole in real samples. We elaborated a carbon paste electrode modified with Al2O3 microparticles that are hydrothermally formed on the graphite carbon sheet. As a working electrode, the different experimental parameters have been optimized. The electrochemical behavior of the antibacterial metronidazole was examined by the proposed sensor is perfectly irreversible. This device presents an excellent electro-catalytic activity for metronidazole reduction, as shown by a peak of maximum metronidazole reduction localized at the position of −0.61v /µAl2O3@CPE relative to Ag/AgCl. The pH effect of PBS shows that the number of protons and electrons was equal. The diffusion coefficient and the electro-catalytic rate constant were evaluated at 6.34x10-4 cm2/s and 3.4 cm3/mol/s respectively. The morphology and chemical composition of the prepared paste have been characterized by SEM, X-ray diffraction and IR, the size of Al2O3 microparticles is about 4.45 µm, the calibration curve has been plotted in the concentration range of 10−3 to 0.5 × 10−6 M using the Differential pulse voltammetry method. The limit of detection (LOD) and limit of quantification (LOQ) were calculated to be 0.253 × 10−6 M and 0.844 × 10−6 M, respectively. The applicability of our µAl2O3@CPE sensors in the determination of Metronidazole in real samples contaminated with the Metronidazole antibacterial, including tap water, river water and urine. The electro-analysis results obtained show a very satisfactory recovery rate of more than 94%.J. ZoubirC. RadaaA. IdlahcenI. BakasA. AssabbaneKeAi Communications Co., Ltd.articleElectro-analysisSensorsMetronidazoleElectrode µAl2O3@CPEMaterials of engineering and construction. Mechanics of materialsTA401-492Energy conservationTJ163.26-163.5ENMaterials Science for Energy Technologies, Vol 4, Iss , Pp 296-306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electro-analysis Sensors Metronidazole Electrode µAl2O3@CPE Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5
spellingShingle	Electro-analysis Sensors Metronidazole Electrode µAl2O3@CPE Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5 J. Zoubir C. Radaa A. Idlahcen I. Bakas A. Assabbane A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water
description	Metronidazole is an anti-parasitic drug of the nitro-5-imidazole class, discovered in 1959. The objective of this research was to construct a highly sensitive sensor to detect Metronidazole in real samples. We elaborated a carbon paste electrode modified with Al2O3 microparticles that are hydrothermally formed on the graphite carbon sheet. As a working electrode, the different experimental parameters have been optimized. The electrochemical behavior of the antibacterial metronidazole was examined by the proposed sensor is perfectly irreversible. This device presents an excellent electro-catalytic activity for metronidazole reduction, as shown by a peak of maximum metronidazole reduction localized at the position of −0.61v /µAl2O3@CPE relative to Ag/AgCl. The pH effect of PBS shows that the number of protons and electrons was equal. The diffusion coefficient and the electro-catalytic rate constant were evaluated at 6.34x10-4 cm2/s and 3.4 cm3/mol/s respectively. The morphology and chemical composition of the prepared paste have been characterized by SEM, X-ray diffraction and IR, the size of Al2O3 microparticles is about 4.45 µm, the calibration curve has been plotted in the concentration range of 10−3 to 0.5 × 10−6 M using the Differential pulse voltammetry method. The limit of detection (LOD) and limit of quantification (LOQ) were calculated to be 0.253 × 10−6 M and 0.844 × 10−6 M, respectively. The applicability of our µAl2O3@CPE sensors in the determination of Metronidazole in real samples contaminated with the Metronidazole antibacterial, including tap water, river water and urine. The electro-analysis results obtained show a very satisfactory recovery rate of more than 94%.
format	article
author	J. Zoubir C. Radaa A. Idlahcen I. Bakas A. Assabbane
author_facet	J. Zoubir C. Radaa A. Idlahcen I. Bakas A. Assabbane
author_sort	J. Zoubir
title	A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water
title_short	A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water
title_full	A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water
title_fullStr	A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water
title_full_unstemmed	A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water
title_sort	new voltammetric sensor for metronidazole based on electro catalytic effect of al2o3 modified carbon graphite. application. urine, tap water and river water
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/e8e215e7d92849bf99f5187145daab04
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A new voltammetric sensor for metronidazole based on electro catalytic effect of Al2O3 modified carbon graphite. Application. Urine, tap water and river water

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