Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.

Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.

To further understand the pharmacological properties of N-oleoylethanolamine (OEA), a naturally occurring lipid that activates peroxisome proliferator-activated receptor alpha (PPARα), we designed sulfamoyl analogs based on its structure. Among the compounds tested, N-octadecyl-N'-propylsulfami...

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Auteurs principaux: Inmaculada Moreno-Santos, Francisco Javier Pavón, Miguel Romero-Cuevas, Antonia Serrano, Carolina Cano, Margarita Suardíaz, Juan Decara, Juan Suarez, Fernando Rodríguez de Fonseca, Manuel Macías-González
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/e8e3c422775b4a99a4cbe5a87e56a9d4
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https://doaj.org/article/e8e3c422775b4a99a4cbe5a87e56a9d4

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