Hepatic HuR modulates lipid homeostasis in response to high-fat diet

Human antigen R (HuR) is a RNA binding protein involved in the regulation of many cellular functions. Here the authors show that, hepatocyte specific deletion of HuR exacerbates high-fat diet-induced NAFLD in mice by regulating transcripts involved in lipid transport and ATP synthesis.

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Autores principales:	Zhuojun Zhang, Chen Zong, Mingyang Jiang, Han Hu, Xiaolei Cheng, Juhua Ni, Xia Yi, Bin Jiang, Feng Tian, Ming-Wen Chang, Wen Su, Lijun Zhu, Jinfan Li, Xueping Xiang, Congxiu Miao, Myriam Gorospe, Rafael de Cabo, Yali Dou, Zhenyu Ju, Jichun Yang, Changtao Jiang, Zhongzhou Yang, Wengong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8e60e544729458cb35c8c4647274ad2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e8e60e544729458cb35c8c4647274ad22021-12-02T17:40:00ZHepatic HuR modulates lipid homeostasis in response to high-fat diet10.1038/s41467-020-16918-x2041-1723https://doaj.org/article/e8e60e544729458cb35c8c4647274ad22020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16918-xhttps://doaj.org/toc/2041-1723Human antigen R (HuR) is a RNA binding protein involved in the regulation of many cellular functions. Here the authors show that, hepatocyte specific deletion of HuR exacerbates high-fat diet-induced NAFLD in mice by regulating transcripts involved in lipid transport and ATP synthesis.Zhuojun ZhangChen ZongMingyang JiangHan HuXiaolei ChengJuhua NiXia YiBin JiangFeng TianMing-Wen ChangWen SuLijun ZhuJinfan LiXueping XiangCongxiu MiaoMyriam GorospeRafael de CaboYali DouZhenyu JuJichun YangChangtao JiangZhongzhou YangWengong WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhuojun Zhang Chen Zong Mingyang Jiang Han Hu Xiaolei Cheng Juhua Ni Xia Yi Bin Jiang Feng Tian Ming-Wen Chang Wen Su Lijun Zhu Jinfan Li Xueping Xiang Congxiu Miao Myriam Gorospe Rafael de Cabo Yali Dou Zhenyu Ju Jichun Yang Changtao Jiang Zhongzhou Yang Wengong Wang Hepatic HuR modulates lipid homeostasis in response to high-fat diet
description	Human antigen R (HuR) is a RNA binding protein involved in the regulation of many cellular functions. Here the authors show that, hepatocyte specific deletion of HuR exacerbates high-fat diet-induced NAFLD in mice by regulating transcripts involved in lipid transport and ATP synthesis.
format	article
author	Zhuojun Zhang Chen Zong Mingyang Jiang Han Hu Xiaolei Cheng Juhua Ni Xia Yi Bin Jiang Feng Tian Ming-Wen Chang Wen Su Lijun Zhu Jinfan Li Xueping Xiang Congxiu Miao Myriam Gorospe Rafael de Cabo Yali Dou Zhenyu Ju Jichun Yang Changtao Jiang Zhongzhou Yang Wengong Wang
author_facet	Zhuojun Zhang Chen Zong Mingyang Jiang Han Hu Xiaolei Cheng Juhua Ni Xia Yi Bin Jiang Feng Tian Ming-Wen Chang Wen Su Lijun Zhu Jinfan Li Xueping Xiang Congxiu Miao Myriam Gorospe Rafael de Cabo Yali Dou Zhenyu Ju Jichun Yang Changtao Jiang Zhongzhou Yang Wengong Wang
author_sort	Zhuojun Zhang
title	Hepatic HuR modulates lipid homeostasis in response to high-fat diet
title_short	Hepatic HuR modulates lipid homeostasis in response to high-fat diet
title_full	Hepatic HuR modulates lipid homeostasis in response to high-fat diet
title_fullStr	Hepatic HuR modulates lipid homeostasis in response to high-fat diet
title_full_unstemmed	Hepatic HuR modulates lipid homeostasis in response to high-fat diet
title_sort	hepatic hur modulates lipid homeostasis in response to high-fat diet
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e8e60e544729458cb35c8c4647274ad2
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Hepatic HuR modulates lipid homeostasis in response to high-fat diet

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