Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis

Masato Matsuoka,1 Nahoko Ogata,2 Kanji Takahashi,3 Yuichi Kinoshita,4 Tetsuya Nishimura11Department of Ophthalmology, Kansai Medical University, Takii Hospital, Osaka, 2Department of Ophthalmology, Nara Medical University, Nara, 3Department of Ophthalmology, Kansai Medical University, Hirakata Hospi...

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Autores principales:	Matsuoka M, Ogata N, Takahashi K, Kinoshita Y, Nishimura T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e8e879771e04478794c7ec8da146e08e
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spelling	oai:doaj.org-article:e8e879771e04478794c7ec8da146e08e2021-12-02T04:55:26ZTwo cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis1177-54671177-5483https://doaj.org/article/e8e879771e04478794c7ec8da146e08e2012-07-01T00:00:00Zhttp://www.dovepress.com/two-cases-of-ocular-sarcoidosis-in-which-vitreous-cytology-was-useful--a10562https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Masato Matsuoka,1 Nahoko Ogata,2 Kanji Takahashi,3 Yuichi Kinoshita,4 Tetsuya Nishimura11Department of Ophthalmology, Kansai Medical University, Takii Hospital, Osaka, 2Department of Ophthalmology, Nara Medical University, Nara, 3Department of Ophthalmology, Kansai Medical University, Hirakata Hospital, Osaka, 4Department of Histopathology, Kansai Medical University, Takii Hospital, Osaka, JapanAbstract: The purpose of this paper is to report two cases of sarcoidosis with conflicting signs in which vitreous cytology was useful for supporting the diagnosis. Case 1 was a 56-year-old man who was referred with blurred vision, and was found to have iridocyclitis, vitreous opacities, and optic neuritis bilaterally. He also had a swelling of both mandibular glands. He received pulsed corticosteroid therapy, but the vitreous opacities and papilledema did not resolve. The second case was a 77-year-old man referred with blurred vision, and both eyes had snowball-like vitreous opacities and optic neuritis. The ocular findings in both cases strongly suggested sarcoidosis, but the systemic findings did not meet the diagnostic criteria for sarcoidosis. We performed pars plana vitrectomy to remove the vitreous opacities, and the collected vitreous samples were sent for cytological analyses. Epithelioid and multinucleated giant cells pathognomonic of sarcoidosis were found in the vitreous samples which enabled us to make a diagnosis of sarcoidosis. Vitreous cytology can help in supporting a diagnosis of sarcoidosis, especially in cases of ocular inflammation suggesting sarcoidosis but systemic findings that do not satisfy the diagnostic criteria for this disease.Keywords: sarcoidosis, cytology, vitreous, pars plana vitrectomy, papilledemaMatsuoka MOgata NTakahashi KKinoshita YNishimura TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1207-1209 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Matsuoka M Ogata N Takahashi K Kinoshita Y Nishimura T Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis
description	Masato Matsuoka,1 Nahoko Ogata,2 Kanji Takahashi,3 Yuichi Kinoshita,4 Tetsuya Nishimura11Department of Ophthalmology, Kansai Medical University, Takii Hospital, Osaka, 2Department of Ophthalmology, Nara Medical University, Nara, 3Department of Ophthalmology, Kansai Medical University, Hirakata Hospital, Osaka, 4Department of Histopathology, Kansai Medical University, Takii Hospital, Osaka, JapanAbstract: The purpose of this paper is to report two cases of sarcoidosis with conflicting signs in which vitreous cytology was useful for supporting the diagnosis. Case 1 was a 56-year-old man who was referred with blurred vision, and was found to have iridocyclitis, vitreous opacities, and optic neuritis bilaterally. He also had a swelling of both mandibular glands. He received pulsed corticosteroid therapy, but the vitreous opacities and papilledema did not resolve. The second case was a 77-year-old man referred with blurred vision, and both eyes had snowball-like vitreous opacities and optic neuritis. The ocular findings in both cases strongly suggested sarcoidosis, but the systemic findings did not meet the diagnostic criteria for sarcoidosis. We performed pars plana vitrectomy to remove the vitreous opacities, and the collected vitreous samples were sent for cytological analyses. Epithelioid and multinucleated giant cells pathognomonic of sarcoidosis were found in the vitreous samples which enabled us to make a diagnosis of sarcoidosis. Vitreous cytology can help in supporting a diagnosis of sarcoidosis, especially in cases of ocular inflammation suggesting sarcoidosis but systemic findings that do not satisfy the diagnostic criteria for this disease.Keywords: sarcoidosis, cytology, vitreous, pars plana vitrectomy, papilledema
format	article
author	Matsuoka M Ogata N Takahashi K Kinoshita Y Nishimura T
author_facet	Matsuoka M Ogata N Takahashi K Kinoshita Y Nishimura T
author_sort	Matsuoka M
title	Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis
title_short	Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis
title_full	Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis
title_fullStr	Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis
title_full_unstemmed	Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis
title_sort	two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/e8e879771e04478794c7ec8da146e08e
work_keys_str_mv	AT matsuokam twocasesofocularsarcoidosisinwhichvitreouscytologywasusefulforsupportingthediagnosis AT ogatan twocasesofocularsarcoidosisinwhichvitreouscytologywasusefulforsupportingthediagnosis AT takahashik twocasesofocularsarcoidosisinwhichvitreouscytologywasusefulforsupportingthediagnosis AT kinoshitay twocasesofocularsarcoidosisinwhichvitreouscytologywasusefulforsupportingthediagnosis AT nishimurat twocasesofocularsarcoidosisinwhichvitreouscytologywasusefulforsupportingthediagnosis
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Two cases of ocular sarcoidosis in which vitreous cytology was useful for supporting the diagnosis

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