Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.

Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.

Sensing and response to environmental cues, such as pH and chloride (Cl-), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compounds that dysregulate Mtb response to high Cl- level...

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Detalles Bibliográficos
Autores principales: Richard C Lavin, Calvin Johnson, Yong-Mo Ahn, Kyle M Kremiller, Matthew Sherwood, Jimmy S Patel, Yan Pan, Riccardo Russo, Nathan J MacGilvary, David Giacalone, Yuzo L Kevorkian, Matthew D Zimmerman, J Fraser Glickman, Joel S Freundlich, Shumin Tan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/e8e92b4c6c2a4557821d17bd95672572
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