Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen

Abstract The aim of this study was to evaluate renal hemodynamics, routine clinical and laboratory parameters used to estimate renal function, and clinical evolution during six months in bitches with mammary carcinomas that underwent mastectomy and were treated (TG) or not (CG) with carprofen for th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cristhian Rene Vargas Estrada, Bruna Fernanda Firmo, Daniele Belchior Vela, Marjury Cristina Maronezi, Ricardo Andrés Ramirez Uscategui, Beatriz Gasser, Marcus Antônio Rossi Feliciano, Letícia Pavan, Luiz Paulo Nogueira Aires, Gabriela Piovan Lima, Andrigo Barboza De Nardi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8ea73fa15494a08a67d26ea6df80864
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e8ea73fa15494a08a67d26ea6df80864
record_format	dspace
spelling	oai:doaj.org-article:e8ea73fa15494a08a67d26ea6df808642021-12-05T12:13:51ZUltrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen10.1038/s41598-021-02781-32045-2322https://doaj.org/article/e8ea73fa15494a08a67d26ea6df808642021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02781-3https://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate renal hemodynamics, routine clinical and laboratory parameters used to estimate renal function, and clinical evolution during six months in bitches with mammary carcinomas that underwent mastectomy and were treated (TG) or not (CG) with carprofen for three months after surgery. Twenty-six bitches with mammary carcinoma were equally distributed into TG that received carprofen 4.4 mg/kg/day for 90 days and CG that did not receive anti-inflammatory medication. Renal artery Doppler flowmetry, contrast-enhanced ultrasound (CEUS) of renal parenchyma, haematological, biochemical and clinical analyses were obtained once a month. These data were compared between groups and time via analysis of variance (ANOVA) in a completely randomized design with repeated measures (P < 0.05). On B-mode ultrasound, the area of the renal artery was greater (P = 0.0003) in the TG. Regarding laboratory findings, haematocrit and haemoglobin were similar in both groups, showing a significant and gradual increase after three months of treatment; MCV, MHC, and MCHC were increased (P < 0.05) and lymphocyte and band counts decreased (P < 0.05) in the TG. Regarding biochemical tests, ALT was the only parameter with a significant difference, being higher (P = 0.0272) in the treated group. It can be concluded that the use of carprofen for 90 days causes minimal changes in renal perfusion, erythrocyte parameters and ALT activity, and reduces the proportion of blood inflammatory cells. Therefore, use of this medication can be carried out safely in patients who require auxiliary cancer treatment.Cristhian Rene Vargas EstradaBruna Fernanda FirmoDaniele Belchior VelaMarjury Cristina MaroneziRicardo Andrés Ramirez UscateguiBeatriz GasserMarcus Antônio Rossi FelicianoLetícia PavanLuiz Paulo Nogueira AiresGabriela Piovan LimaAndrigo Barboza De NardiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristhian Rene Vargas Estrada Bruna Fernanda Firmo Daniele Belchior Vela Marjury Cristina Maronezi Ricardo Andrés Ramirez Uscategui Beatriz Gasser Marcus Antônio Rossi Feliciano Letícia Pavan Luiz Paulo Nogueira Aires Gabriela Piovan Lima Andrigo Barboza De Nardi Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen
description	Abstract The aim of this study was to evaluate renal hemodynamics, routine clinical and laboratory parameters used to estimate renal function, and clinical evolution during six months in bitches with mammary carcinomas that underwent mastectomy and were treated (TG) or not (CG) with carprofen for three months after surgery. Twenty-six bitches with mammary carcinoma were equally distributed into TG that received carprofen 4.4 mg/kg/day for 90 days and CG that did not receive anti-inflammatory medication. Renal artery Doppler flowmetry, contrast-enhanced ultrasound (CEUS) of renal parenchyma, haematological, biochemical and clinical analyses were obtained once a month. These data were compared between groups and time via analysis of variance (ANOVA) in a completely randomized design with repeated measures (P < 0.05). On B-mode ultrasound, the area of the renal artery was greater (P = 0.0003) in the TG. Regarding laboratory findings, haematocrit and haemoglobin were similar in both groups, showing a significant and gradual increase after three months of treatment; MCV, MHC, and MCHC were increased (P < 0.05) and lymphocyte and band counts decreased (P < 0.05) in the TG. Regarding biochemical tests, ALT was the only parameter with a significant difference, being higher (P = 0.0272) in the treated group. It can be concluded that the use of carprofen for 90 days causes minimal changes in renal perfusion, erythrocyte parameters and ALT activity, and reduces the proportion of blood inflammatory cells. Therefore, use of this medication can be carried out safely in patients who require auxiliary cancer treatment.
format	article
author	Cristhian Rene Vargas Estrada Bruna Fernanda Firmo Daniele Belchior Vela Marjury Cristina Maronezi Ricardo Andrés Ramirez Uscategui Beatriz Gasser Marcus Antônio Rossi Feliciano Letícia Pavan Luiz Paulo Nogueira Aires Gabriela Piovan Lima Andrigo Barboza De Nardi
author_facet	Cristhian Rene Vargas Estrada Bruna Fernanda Firmo Daniele Belchior Vela Marjury Cristina Maronezi Ricardo Andrés Ramirez Uscategui Beatriz Gasser Marcus Antônio Rossi Feliciano Letícia Pavan Luiz Paulo Nogueira Aires Gabriela Piovan Lima Andrigo Barboza De Nardi
author_sort	Cristhian Rene Vargas Estrada
title	Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen
title_short	Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen
title_full	Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen
title_fullStr	Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen
title_full_unstemmed	Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen
title_sort	ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8ea73fa15494a08a67d26ea6df80864
work_keys_str_mv	AT cristhianrenevargasestrada ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT brunafernandafirmo ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT danielebelchiorvela ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT marjurycristinamaronezi ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT ricardoandresramirezuscategui ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT beatrizgasser ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT marcusantoniorossifeliciano ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT leticiapavan ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT luizpaulonogueiraaires ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT gabrielapiovanlima ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen AT andrigobarbozadenardi ultrasonographicassessmentofrenalperfusioninbitcheswithmammarycarcinomatreatedwithlongtermcarprofen
_version_	1718372168211890176

Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen

Ejemplares similares