Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation

Abstract Body composition and myosteatosis affect clinical outcomes in orthotopic liver transplantation (OLT). Here we aimed to compare the value and limitations of various selection criteria to define pre-transplant myosteatosis in the assessment of short- and long-term outcomes following OLT. We r...

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Autores principales:	Franziska Alexandra Meister, Jan Bednarsch, Iakovos Amygdalos, Joerg Boecker, Pavel Strnad, Philipp Bruners, Sven Arke Lang, Tom Florian Ulmer, Lara Heij, Daniel Antonio Morales Santana, Wen-Jia Liu, Georg Lurje, Ulf Peter Neumann, Zoltan Czigany
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8f2187da9ad4b0799e5de46cc3eb31c
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spelling	oai:doaj.org-article:e8f2187da9ad4b0799e5de46cc3eb31c2021-12-02T16:31:57ZVarious myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation10.1038/s41598-021-92798-52045-2322https://doaj.org/article/e8f2187da9ad4b0799e5de46cc3eb31c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92798-5https://doaj.org/toc/2045-2322Abstract Body composition and myosteatosis affect clinical outcomes in orthotopic liver transplantation (OLT). Here we aimed to compare the value and limitations of various selection criteria to define pre-transplant myosteatosis in the assessment of short- and long-term outcomes following OLT. We retrospectively analyzed the data of 264 consecutive recipients who underwent deceased donor OLT at a German university medical centre. Myosteatosis was evaluated by preoperative computed-tomography-based segmentation. Patients were stratified using muscle radiation attenuation of the whole muscle area (L3Muslce-RA), psoas RA (L3Psoas-RA) and intramuscular adipose tissue content (IMAC) values. L3Muslce-RA, L3Psoas-RA and IMAC performed well without major differences and identified patients at risk for inferior outcomes in the group analysis. Quartile-based analyses, receiver operating characteristic curve and correlation analyses showed a superior association of L3Muslce-RA with perioperative outcomes when compared to L3Psoas-RA and L3IMAC. Long-term outcome did not show any major differences between the used selection criteria. This study confirms the prognostic role of myosteatosis in OLT with a particularly strong value in the perioperative phase. Although, based on our data, L3Muscle-RA might be the most suitable and recommended selection criterion to assess CT-based myosteatosis when compared to L3Psoas-RA and L3IMAC, further studies are warranted to validate these findings.Franziska Alexandra MeisterJan BednarschIakovos AmygdalosJoerg BoeckerPavel StrnadPhilipp BrunersSven Arke LangTom Florian UlmerLara HeijDaniel Antonio Morales SantanaWen-Jia LiuGeorg LurjeUlf Peter NeumannZoltan CziganyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Franziska Alexandra Meister Jan Bednarsch Iakovos Amygdalos Joerg Boecker Pavel Strnad Philipp Bruners Sven Arke Lang Tom Florian Ulmer Lara Heij Daniel Antonio Morales Santana Wen-Jia Liu Georg Lurje Ulf Peter Neumann Zoltan Czigany Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation
description	Abstract Body composition and myosteatosis affect clinical outcomes in orthotopic liver transplantation (OLT). Here we aimed to compare the value and limitations of various selection criteria to define pre-transplant myosteatosis in the assessment of short- and long-term outcomes following OLT. We retrospectively analyzed the data of 264 consecutive recipients who underwent deceased donor OLT at a German university medical centre. Myosteatosis was evaluated by preoperative computed-tomography-based segmentation. Patients were stratified using muscle radiation attenuation of the whole muscle area (L3Muslce-RA), psoas RA (L3Psoas-RA) and intramuscular adipose tissue content (IMAC) values. L3Muslce-RA, L3Psoas-RA and IMAC performed well without major differences and identified patients at risk for inferior outcomes in the group analysis. Quartile-based analyses, receiver operating characteristic curve and correlation analyses showed a superior association of L3Muslce-RA with perioperative outcomes when compared to L3Psoas-RA and L3IMAC. Long-term outcome did not show any major differences between the used selection criteria. This study confirms the prognostic role of myosteatosis in OLT with a particularly strong value in the perioperative phase. Although, based on our data, L3Muscle-RA might be the most suitable and recommended selection criterion to assess CT-based myosteatosis when compared to L3Psoas-RA and L3IMAC, further studies are warranted to validate these findings.
format	article
author	Franziska Alexandra Meister Jan Bednarsch Iakovos Amygdalos Joerg Boecker Pavel Strnad Philipp Bruners Sven Arke Lang Tom Florian Ulmer Lara Heij Daniel Antonio Morales Santana Wen-Jia Liu Georg Lurje Ulf Peter Neumann Zoltan Czigany
author_facet	Franziska Alexandra Meister Jan Bednarsch Iakovos Amygdalos Joerg Boecker Pavel Strnad Philipp Bruners Sven Arke Lang Tom Florian Ulmer Lara Heij Daniel Antonio Morales Santana Wen-Jia Liu Georg Lurje Ulf Peter Neumann Zoltan Czigany
author_sort	Franziska Alexandra Meister
title	Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation
title_short	Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation
title_full	Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation
title_fullStr	Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation
title_full_unstemmed	Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation
title_sort	various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8f2187da9ad4b0799e5de46cc3eb31c
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Various myosteatosis selection criteria and their value in the assessment of short- and long-term outcomes following liver transplantation

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