Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia

Abstract There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids. We report that L-glutathione ethyl ester (GSHee) may be such a novel compound. In th...

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Autores principales: Michael W. Jenkins, Faiza Khalid, Santhosh M. Baby, Walter J. May, Alex P. Young, James N. Bates, Feixiong Cheng, James M. Seckler, Stephen J. Lewis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e8f4803ec10a4a88badb5c1309e08a21
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