Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth

Growth of the mammalian heart is controlled by Hippo signalling but how this is regulated is unclear. Here, the authors show that Fat4 (an atypical cadherin) acts upstream of Hippo signalling and Fat4 mutant mice have thicker myocardium, which is mediated by the scaffold Amot1 and transcription fact...

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Autores principales:	Chiara V. Ragni, Nicolas Diguet, Jean-François Le Garrec, Marta Novotova, Tatiana P. Resende, Sorin Pop, Nicolas Charon, Laurent Guillemot, Lisa Kitasato, Caroline Badouel, Alexandre Dufour, Jean-Christophe Olivo-Marin, Alain Trouvé, Helen McNeill, Sigolène M Meilhac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8f4fd524d4c427fa1e8c9b37e7353f2
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spelling	oai:doaj.org-article:e8f4fd524d4c427fa1e8c9b37e7353f22021-12-02T17:06:13ZAmotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth10.1038/ncomms145822041-1723https://doaj.org/article/e8f4fd524d4c427fa1e8c9b37e7353f22017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14582https://doaj.org/toc/2041-1723Growth of the mammalian heart is controlled by Hippo signalling but how this is regulated is unclear. Here, the authors show that Fat4 (an atypical cadherin) acts upstream of Hippo signalling and Fat4 mutant mice have thicker myocardium, which is mediated by the scaffold Amot1 and transcription factor Yap1.Chiara V. RagniNicolas DiguetJean-François Le GarrecMarta NovotovaTatiana P. ResendeSorin PopNicolas CharonLaurent GuillemotLisa KitasatoCaroline BadouelAlexandre DufourJean-Christophe Olivo-MarinAlain TrouvéHelen McNeillSigolène M MeilhacNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiara V. Ragni Nicolas Diguet Jean-François Le Garrec Marta Novotova Tatiana P. Resende Sorin Pop Nicolas Charon Laurent Guillemot Lisa Kitasato Caroline Badouel Alexandre Dufour Jean-Christophe Olivo-Marin Alain Trouvé Helen McNeill Sigolène M Meilhac Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
description	Growth of the mammalian heart is controlled by Hippo signalling but how this is regulated is unclear. Here, the authors show that Fat4 (an atypical cadherin) acts upstream of Hippo signalling and Fat4 mutant mice have thicker myocardium, which is mediated by the scaffold Amot1 and transcription factor Yap1.
format	article
author	Chiara V. Ragni Nicolas Diguet Jean-François Le Garrec Marta Novotova Tatiana P. Resende Sorin Pop Nicolas Charon Laurent Guillemot Lisa Kitasato Caroline Badouel Alexandre Dufour Jean-Christophe Olivo-Marin Alain Trouvé Helen McNeill Sigolène M Meilhac
author_facet	Chiara V. Ragni Nicolas Diguet Jean-François Le Garrec Marta Novotova Tatiana P. Resende Sorin Pop Nicolas Charon Laurent Guillemot Lisa Kitasato Caroline Badouel Alexandre Dufour Jean-Christophe Olivo-Marin Alain Trouvé Helen McNeill Sigolène M Meilhac
author_sort	Chiara V. Ragni
title	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
title_short	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
title_full	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
title_fullStr	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
title_full_unstemmed	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
title_sort	amotl1 mediates sequestration of the hippo effector yap1 downstream of fat4 to restrict heart growth
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e8f4fd524d4c427fa1e8c9b37e7353f2
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Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth

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