Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?

Tabitha Y Chan, Poh Wee Tan, Johann I Tang Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore Abstract: Whole breast external beam radiotherapy (WBEBRT) is commonly used as an essential arm in the treatment management of women with early-stage breast cancer....

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Autores principales: Chan TY, Tan PW, Tang JI
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Lenguaje:EN
Publicado: Dove Medical Press 2017
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Acceso en línea:https://doaj.org/article/e8f6f7416a9f45b18d7de802c3bb5789
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spelling oai:doaj.org-article:e8f6f7416a9f45b18d7de802c3bb57892021-12-02T02:20:24ZIntensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?1179-1314https://doaj.org/article/e8f6f7416a9f45b18d7de802c3bb57892017-03-01T00:00:00Zhttps://www.dovepress.com/intensity-modulated-radiation-therapy-for-early-stage-breast-cancer-is-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Tabitha Y Chan, Poh Wee Tan, Johann I Tang Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore Abstract: Whole breast external beam radiotherapy (WBEBRT) is commonly used as an essential arm in the treatment management of women with early-stage breast cancer. Dosimetry planning for conventional WBEBRT typically involves a pair of tangential fields. Advancement in radiation technology and techniques has the potential to improve treatment outcomes with clinically meaningful long-term benefits. However, this advancement must be balanced with safety and improved efficacy. Intensity-modulated radiation therapy (IMRT) is an advanced technique that shows promise in improving the planning process and radiation delivery. Early data on utilizing IMRT for WBEBRT demonstrate more homogenous dose distribution with reduction in organs at risk doses. This translates to toxicities reduction. The two common descriptors for IMRT are forward-planning “fields in field” and inverse planning. Unlike IMRT for other organs, the aim of IMRT for breast planning is to achieve dose homogeneity and not organ conformality. The aim of this paper was to evaluate whether IMRT is ready for prime time based on these three points: 1) workload impact, 2) the clinical impact on the patient’s quality of life, and 3) the appropriateness and applicability to clinical practice. Keywords: early-stage breast cancer, radiotherapy, intensity-modulated radiation therapy, workload impact, quality of life, clinical practiceChan TYTan PWTang JIDove Medical PressarticleEarly stage breast cancerradiotherapyintensity modulated radiation therapyworkload impactquality of lifeclinical practiceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 177-183 (2017)
institution DOAJ
collection DOAJ
language EN
topic Early stage breast cancer
radiotherapy
intensity modulated radiation therapy
workload impact
quality of life
clinical practice
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Early stage breast cancer
radiotherapy
intensity modulated radiation therapy
workload impact
quality of life
clinical practice
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Chan TY
Tan PW
Tang JI
Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?
description Tabitha Y Chan, Poh Wee Tan, Johann I Tang Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore Abstract: Whole breast external beam radiotherapy (WBEBRT) is commonly used as an essential arm in the treatment management of women with early-stage breast cancer. Dosimetry planning for conventional WBEBRT typically involves a pair of tangential fields. Advancement in radiation technology and techniques has the potential to improve treatment outcomes with clinically meaningful long-term benefits. However, this advancement must be balanced with safety and improved efficacy. Intensity-modulated radiation therapy (IMRT) is an advanced technique that shows promise in improving the planning process and radiation delivery. Early data on utilizing IMRT for WBEBRT demonstrate more homogenous dose distribution with reduction in organs at risk doses. This translates to toxicities reduction. The two common descriptors for IMRT are forward-planning “fields in field” and inverse planning. Unlike IMRT for other organs, the aim of IMRT for breast planning is to achieve dose homogeneity and not organ conformality. The aim of this paper was to evaluate whether IMRT is ready for prime time based on these three points: 1) workload impact, 2) the clinical impact on the patient’s quality of life, and 3) the appropriateness and applicability to clinical practice. Keywords: early-stage breast cancer, radiotherapy, intensity-modulated radiation therapy, workload impact, quality of life, clinical practice
format article
author Chan TY
Tan PW
Tang JI
author_facet Chan TY
Tan PW
Tang JI
author_sort Chan TY
title Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?
title_short Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?
title_full Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?
title_fullStr Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?
title_full_unstemmed Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?
title_sort intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/e8f6f7416a9f45b18d7de802c3bb5789
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AT tanpw intensitymodulatedradiationtherapyforearlystagebreastcancerisitreadyforprimetime
AT tangji intensitymodulatedradiationtherapyforearlystagebreastcancerisitreadyforprimetime
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