Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier

Yongjiu Lv,* Jingjing Li,* Huali Chen, Yan Bai, Liangke Zhang Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, China *These authors contributed equally to thi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lv Y, Li J, Chen H, Bai Y, Zhang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Glycyrrhetinic acid Mesoporous silica nanoparticle Tumor targeting HepG2 cells Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e8f7d655d6764095a10f5518349c1a6d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e8f7d655d6764095a10f5518349c1a6d
record_format	dspace
spelling	oai:doaj.org-article:e8f7d655d6764095a10f5518349c1a6d2021-12-02T06:37:58ZGlycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier1178-2013https://doaj.org/article/e8f7d655d6764095a10f5518349c1a6d2017-06-01T00:00:00Zhttps://www.dovepress.com/glycyrrhetinic-acid-functionalized-mesoporous-silica-nanoparticles-as--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yongjiu Lv,* Jingjing Li,* Huali Chen, Yan Bai, Liangke Zhang Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, China *These authors contributed equally to this work Abstract: In this study, a glycyrrhetinic acid-functionalized mesoporous silica nanoparticle (MSN-GA) was prepared for active tumor targeting. MSN-GA exhibited satisfactory loading capacity for insoluble drugs, uniform size distribution, and specific tumor cell targeting. Glycyrrhetinic acid, a hepatocellular carcinoma-targeting group, was covalently decorated on the surface of MSN via an amido bond. The successful synthesis of MSN-GA was validated by the results of Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), and zeta potential measurement. TEM images revealed the spherical morphology and uniform size distribution of the naked MSN and MSN-GA. Curcumin (CUR), an insoluble model drug, was loaded into MSN-GA (denoted as MSN-GA-CUR) with a high-loading capacity (8.78%±1.24%). The results of the in vitro cellular experiment demonstrated that MSN-GA-CUR significantly enhanced cytotoxicity and cellular uptake toward hepatocellular carcinoma (HepG2) cells via a specific GA receptor-mediated endocytosis mechanism. The results of this study provide a promising nanoplatform for the targeting of hepatocellular carcinoma. Keywords: active tumor targeting, silica nanoparticle, drug loading capacity, HepG2 cellsLv YLi JChen HBai YZhang LDove Medical PressarticleGlycyrrhetinic acidMesoporous silica nanoparticleTumor targetingHepG2 cellsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4361-4370 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glycyrrhetinic acid Mesoporous silica nanoparticle Tumor targeting HepG2 cells Medicine (General) R5-920
spellingShingle	Glycyrrhetinic acid Mesoporous silica nanoparticle Tumor targeting HepG2 cells Medicine (General) R5-920 Lv Y Li J Chen H Bai Y Zhang L Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
description	Yongjiu Lv,* Jingjing Li,* Huali Chen, Yan Bai, Liangke Zhang Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, China *These authors contributed equally to this work Abstract: In this study, a glycyrrhetinic acid-functionalized mesoporous silica nanoparticle (MSN-GA) was prepared for active tumor targeting. MSN-GA exhibited satisfactory loading capacity for insoluble drugs, uniform size distribution, and specific tumor cell targeting. Glycyrrhetinic acid, a hepatocellular carcinoma-targeting group, was covalently decorated on the surface of MSN via an amido bond. The successful synthesis of MSN-GA was validated by the results of Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), and zeta potential measurement. TEM images revealed the spherical morphology and uniform size distribution of the naked MSN and MSN-GA. Curcumin (CUR), an insoluble model drug, was loaded into MSN-GA (denoted as MSN-GA-CUR) with a high-loading capacity (8.78%±1.24%). The results of the in vitro cellular experiment demonstrated that MSN-GA-CUR significantly enhanced cytotoxicity and cellular uptake toward hepatocellular carcinoma (HepG2) cells via a specific GA receptor-mediated endocytosis mechanism. The results of this study provide a promising nanoplatform for the targeting of hepatocellular carcinoma. Keywords: active tumor targeting, silica nanoparticle, drug loading capacity, HepG2 cells
format	article
author	Lv Y Li J Chen H Bai Y Zhang L
author_facet	Lv Y Li J Chen H Bai Y Zhang L
author_sort	Lv Y
title	Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
title_short	Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
title_full	Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
title_fullStr	Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
title_full_unstemmed	Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
title_sort	glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e8f7d655d6764095a10f5518349c1a6d
work_keys_str_mv	AT lvy glycyrrhetinicacidfunctionalizedmesoporoussilicananoparticlesashepatocellularcarcinomatargeteddrugcarrier AT lij glycyrrhetinicacidfunctionalizedmesoporoussilicananoparticlesashepatocellularcarcinomatargeteddrugcarrier AT chenh glycyrrhetinicacidfunctionalizedmesoporoussilicananoparticlesashepatocellularcarcinomatargeteddrugcarrier AT baiy glycyrrhetinicacidfunctionalizedmesoporoussilicananoparticlesashepatocellularcarcinomatargeteddrugcarrier AT zhangl glycyrrhetinicacidfunctionalizedmesoporoussilicananoparticlesashepatocellularcarcinomatargeteddrugcarrier
_version_	1718399845520113664

Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier

Ejemplares similares