Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.

<h4>Background</h4>To monitor the impact of human papillomavirus types 16 and 18 vaccine on HPV infection dynamics in the Netherlands, we started an ongoing study in sexually transmitted infection (STI) clinics in 2009. Here, we analyze baseline type-specific HPV DNA and HPV-specific ant...

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Autores principales: Henrike J Vriend, Johannes A Bogaards, Fiona R M van der Klis, Mirte Scherpenisse, Hein J Boot, Audrey J King, Marianne A B van der Sande, Medical Microbiological Laboratories, Municipal Health Services
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/e8fae27f8a554fc98aaac28b7aeb0e73
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spelling oai:doaj.org-article:e8fae27f8a554fc98aaac28b7aeb0e732021-11-18T07:48:11ZPatterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.1932-620310.1371/journal.pone.0060696https://doaj.org/article/e8fae27f8a554fc98aaac28b7aeb0e732013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23637760/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To monitor the impact of human papillomavirus types 16 and 18 vaccine on HPV infection dynamics in the Netherlands, we started an ongoing study in sexually transmitted infection (STI) clinics in 2009. Here, we analyze baseline type-specific HPV DNA and HPV-specific antibody positivity rates.<h4>Methods</h4>We enrolled 3569 men and women, 16-24 years of age, from 14 STI clinics, and estimated genital and anal HPV DNA and antibody positivity rates of 7 main carcinogenic HPV types. Generalized estimating equations regression analyses were applied to determine risk factors for, and associations between, type-specific HPV DNA and antibody positivity.<h4>Results</h4>Genital HPV DNA positivity rates were higher in women than in men; anal HPV DNA was especially high in men who have sex with men (MSM). HPV antibody seropositivity rates were also highest in women and MSM. High-risk sexual behavior was predictive of both HPV DNA and antibody positivity. Despite a strong correlation in serological profiles for multiple HPV types, seropositivity was independently associated with homologous HPV DNA detection.<h4>Conclusions</h4>HPV DNA and antibody positivity rates are higher in women and MSM than in heterosexual men, but their association is similar across gender. This suggests a site-specific natural course of infection.Henrike J VriendJohannes A BogaardsFiona R M van der KlisMirte ScherpenisseHein J BootAudrey J KingMarianne A B van der SandeMedical Microbiological Laboratories, Municipal Health ServicesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60696 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Henrike J Vriend
Johannes A Bogaards
Fiona R M van der Klis
Mirte Scherpenisse
Hein J Boot
Audrey J King
Marianne A B van der Sande
Medical Microbiological Laboratories, Municipal Health Services
Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.
description <h4>Background</h4>To monitor the impact of human papillomavirus types 16 and 18 vaccine on HPV infection dynamics in the Netherlands, we started an ongoing study in sexually transmitted infection (STI) clinics in 2009. Here, we analyze baseline type-specific HPV DNA and HPV-specific antibody positivity rates.<h4>Methods</h4>We enrolled 3569 men and women, 16-24 years of age, from 14 STI clinics, and estimated genital and anal HPV DNA and antibody positivity rates of 7 main carcinogenic HPV types. Generalized estimating equations regression analyses were applied to determine risk factors for, and associations between, type-specific HPV DNA and antibody positivity.<h4>Results</h4>Genital HPV DNA positivity rates were higher in women than in men; anal HPV DNA was especially high in men who have sex with men (MSM). HPV antibody seropositivity rates were also highest in women and MSM. High-risk sexual behavior was predictive of both HPV DNA and antibody positivity. Despite a strong correlation in serological profiles for multiple HPV types, seropositivity was independently associated with homologous HPV DNA detection.<h4>Conclusions</h4>HPV DNA and antibody positivity rates are higher in women and MSM than in heterosexual men, but their association is similar across gender. This suggests a site-specific natural course of infection.
format article
author Henrike J Vriend
Johannes A Bogaards
Fiona R M van der Klis
Mirte Scherpenisse
Hein J Boot
Audrey J King
Marianne A B van der Sande
Medical Microbiological Laboratories, Municipal Health Services
author_facet Henrike J Vriend
Johannes A Bogaards
Fiona R M van der Klis
Mirte Scherpenisse
Hein J Boot
Audrey J King
Marianne A B van der Sande
Medical Microbiological Laboratories, Municipal Health Services
author_sort Henrike J Vriend
title Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.
title_short Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.
title_full Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.
title_fullStr Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.
title_full_unstemmed Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection.
title_sort patterns of human papillomavirus dna and antibody positivity in young males and females, suggesting a site-specific natural course of infection.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/e8fae27f8a554fc98aaac28b7aeb0e73
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