Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression.

Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression.

Staphylococcus aureus biofilms are associated with chronic skin infections and are orders of magnitude more resistant to antimicrobials and host responses. S. aureus contains conserved nonribosomal peptide synthetases that produce the cyclic dipeptides tyrvalin and phevalin (aureusimine A and B, res...

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Main Authors: Patrick R Secor, Laura K Jennings, Garth A James, Kelly R Kirker, Elinor Delancey Pulcini, Kate McInnerney, Robin Gerlach, Tom Livinghouse, Jonathan K Hilmer, Brian Bothner, Philip Fleckman, John E Olerud, Philip S Stewart
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/e8fec58d4d754c1db632c5dc357ec1ae
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