Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.

<h4>Objective</h4>To clarify whether antiparkinsonian drugs contribute to nocturnal sleep disturbances in patients with Parkinson's disease (PD).<h4>Background</h4>Although the major antiparkinsonian drugs L-dopa and dopamine agonists (DAs) have been found to affect slee...

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Autores principales: Soutarou Taguchi, Hirofumi Koide, Hiroko Oiwa, Miku Hayashi, Kazuhiro Ogawa, Chihiro Ito, Koji Nakashima, Tomoko Yuasa, Akihiro Yasumoto, Hiroaki Ando, Akifumi Fujikake, Takaaki Fukuoka, Keisuke Tokui, Masayuki Izumi, Yuka Tsunoda, Yuichi Kawagashira, Yohei Okada, Jun-Ichi Niwa, Manabu Doyu
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:e8ffd43dcce34cb4b784d0d96a8bc3792021-12-02T20:09:02ZAntiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.1932-620310.1371/journal.pone.0255274https://doaj.org/article/e8ffd43dcce34cb4b784d0d96a8bc3792021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255274https://doaj.org/toc/1932-6203<h4>Objective</h4>To clarify whether antiparkinsonian drugs contribute to nocturnal sleep disturbances in patients with Parkinson's disease (PD).<h4>Background</h4>Although the major antiparkinsonian drugs L-dopa and dopamine agonists (DAs) have been found to affect sleep, little is known about the effects of specific drugs on sleep in PD patients.<h4>Methods</h4>The study participants consisted of 112 PD patients (median age 72.5 years [inter-quartile range: IQR 65-79]; mean disease duration 8.44 years [standard deviation: 7.33]; median Hoehn and Yahr stage 3 [IQR 2-3.75]) taking one of three types of non-ergot extended-release DAs (rotigotine 32; pramipexole 44; ropinirole 36) with or without L-dopa (median daily total dosage of antiparkinsonian drugs 525.5 mg [IQR 376.25-658] levodopa equivalent dose [LED]). Participants were assessed using the PD Sleep Scale-2 (PDSS-2).<h4>Results</h4>For the whole PD patient cohort, the PDSS-2 sleep disturbance domain score and the scores for item 1 assessing sleep quality and item 8 assessing nocturia were positively correlated with daily total dosage of antiparkinsonian drugs and dosage of L-dopa, but not with the dosage of DAs. Sub-analysis according to DA treatment revealed that DA dosage was not correlated with item 1 or 8 score in any of the subgroups. The LED ratio of rotigotine to the total dosage of antiparkinsonian drugs was inversely correlated with the item 1 score.<h4>Conclusions</h4>These data suggest that antiparkinsonian drugs, in particular L-dopa, adversely affect nocturnal sleep in PD patients, especially in terms of sleep quality and nocturia. Thus, adjusting both the total dosage of antiparkinsonian drugs and the dose-ratio of L-dopa might be key actions for alleviating poor sleep quality in patients with PD. Among DAs, we found a clear positive correlation between the dose-ratio of rotigotine and sleep quality. Thus, partial L-dopa replacement with rotigotine could improve sleep quality in patients with PD.Soutarou TaguchiHirofumi KoideHiroko OiwaMiku HayashiKazuhiro OgawaChihiro ItoKoji NakashimaTomoko YuasaAkihiro YasumotoHiroaki AndoAkifumi FujikakeTakaaki FukuokaKeisuke TokuiMasayuki IzumiYuka TsunodaYuichi KawagashiraYohei OkadaJun-Ichi NiwaManabu DoyuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255274 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Soutarou Taguchi
Hirofumi Koide
Hiroko Oiwa
Miku Hayashi
Kazuhiro Ogawa
Chihiro Ito
Koji Nakashima
Tomoko Yuasa
Akihiro Yasumoto
Hiroaki Ando
Akifumi Fujikake
Takaaki Fukuoka
Keisuke Tokui
Masayuki Izumi
Yuka Tsunoda
Yuichi Kawagashira
Yohei Okada
Jun-Ichi Niwa
Manabu Doyu
Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.
description <h4>Objective</h4>To clarify whether antiparkinsonian drugs contribute to nocturnal sleep disturbances in patients with Parkinson's disease (PD).<h4>Background</h4>Although the major antiparkinsonian drugs L-dopa and dopamine agonists (DAs) have been found to affect sleep, little is known about the effects of specific drugs on sleep in PD patients.<h4>Methods</h4>The study participants consisted of 112 PD patients (median age 72.5 years [inter-quartile range: IQR 65-79]; mean disease duration 8.44 years [standard deviation: 7.33]; median Hoehn and Yahr stage 3 [IQR 2-3.75]) taking one of three types of non-ergot extended-release DAs (rotigotine 32; pramipexole 44; ropinirole 36) with or without L-dopa (median daily total dosage of antiparkinsonian drugs 525.5 mg [IQR 376.25-658] levodopa equivalent dose [LED]). Participants were assessed using the PD Sleep Scale-2 (PDSS-2).<h4>Results</h4>For the whole PD patient cohort, the PDSS-2 sleep disturbance domain score and the scores for item 1 assessing sleep quality and item 8 assessing nocturia were positively correlated with daily total dosage of antiparkinsonian drugs and dosage of L-dopa, but not with the dosage of DAs. Sub-analysis according to DA treatment revealed that DA dosage was not correlated with item 1 or 8 score in any of the subgroups. The LED ratio of rotigotine to the total dosage of antiparkinsonian drugs was inversely correlated with the item 1 score.<h4>Conclusions</h4>These data suggest that antiparkinsonian drugs, in particular L-dopa, adversely affect nocturnal sleep in PD patients, especially in terms of sleep quality and nocturia. Thus, adjusting both the total dosage of antiparkinsonian drugs and the dose-ratio of L-dopa might be key actions for alleviating poor sleep quality in patients with PD. Among DAs, we found a clear positive correlation between the dose-ratio of rotigotine and sleep quality. Thus, partial L-dopa replacement with rotigotine could improve sleep quality in patients with PD.
format article
author Soutarou Taguchi
Hirofumi Koide
Hiroko Oiwa
Miku Hayashi
Kazuhiro Ogawa
Chihiro Ito
Koji Nakashima
Tomoko Yuasa
Akihiro Yasumoto
Hiroaki Ando
Akifumi Fujikake
Takaaki Fukuoka
Keisuke Tokui
Masayuki Izumi
Yuka Tsunoda
Yuichi Kawagashira
Yohei Okada
Jun-Ichi Niwa
Manabu Doyu
author_facet Soutarou Taguchi
Hirofumi Koide
Hiroko Oiwa
Miku Hayashi
Kazuhiro Ogawa
Chihiro Ito
Koji Nakashima
Tomoko Yuasa
Akihiro Yasumoto
Hiroaki Ando
Akifumi Fujikake
Takaaki Fukuoka
Keisuke Tokui
Masayuki Izumi
Yuka Tsunoda
Yuichi Kawagashira
Yohei Okada
Jun-Ichi Niwa
Manabu Doyu
author_sort Soutarou Taguchi
title Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.
title_short Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.
title_full Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.
title_fullStr Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.
title_full_unstemmed Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.
title_sort antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with parkinson's disease.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/e8ffd43dcce34cb4b784d0d96a8bc379
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