Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation

Eleftheria Hatzimichael1, Mark Tuthill21Department of Haematology, Medical School of Ioannina, University of Ioannina, Ioannina, Greece; 2Department of Medical Oncology, Hammersmith Hospital, Imperial College National Health Service Trust, London, UKAbstract: More than 25,000 hematopoietic stem cell...

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Autores principales: Eleftheria Hatzimichael, Mark Tuthill
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2010
Materias:
Cytology
QH573-671
Acceso en línea:https://doaj.org/article/e90059b8908b40438c33d6157ee5e5e2
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spelling oai:doaj.org-article:e90059b8908b40438c33d6157ee5e5e22021-12-02T03:12:13ZHematopoietic stem cell transplantation1178-6957https://doaj.org/article/e90059b8908b40438c33d6157ee5e5e22010-08-01T00:00:00Zhttp://www.dovepress.com/hematopoietic-stem-cell-transplantation-a5132https://doaj.org/toc/1178-6957Eleftheria Hatzimichael1, Mark Tuthill21Department of Haematology, Medical School of Ioannina, University of Ioannina, Ioannina, Greece; 2Department of Medical Oncology, Hammersmith Hospital, Imperial College National Health Service Trust, London, UKAbstract: More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell “rescue.” Autologous HSCT is performed using the patient’s own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor–recipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications.Keywords: hematopoietic stem cell transplantation, complications Eleftheria HatzimichaelMark TuthillDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2010, Iss default, Pp 105-117 (2010)
institution DOAJ
collection DOAJ
language EN
topic Cytology
QH573-671
spellingShingle Cytology
QH573-671
Eleftheria Hatzimichael
Mark Tuthill
Hematopoietic stem cell transplantation
description Eleftheria Hatzimichael1, Mark Tuthill21Department of Haematology, Medical School of Ioannina, University of Ioannina, Ioannina, Greece; 2Department of Medical Oncology, Hammersmith Hospital, Imperial College National Health Service Trust, London, UKAbstract: More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell “rescue.” Autologous HSCT is performed using the patient’s own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor–recipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications.Keywords: hematopoietic stem cell transplantation, complications
format article
author Eleftheria Hatzimichael
Mark Tuthill
author_facet Eleftheria Hatzimichael
Mark Tuthill
author_sort Eleftheria Hatzimichael
title Hematopoietic stem cell transplantation
title_short Hematopoietic stem cell transplantation
title_full Hematopoietic stem cell transplantation
title_fullStr Hematopoietic stem cell transplantation
title_full_unstemmed Hematopoietic stem cell transplantation
title_sort hematopoietic stem cell transplantation
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/e90059b8908b40438c33d6157ee5e5e2
work_keys_str_mv AT eleftheriahatzimichael hematopoieticstemcelltransplantation
AT marktuthill hematopoieticstemcelltransplantation
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