Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellul...

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Autores principales:	Celia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment, Jean Mariani, Ryuichi Shigemoto, David A DiGregorio, Rachel M Sherrard, Laurence Cathala
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	interneuron dendritic integration synaptic transmission development cerebellum neuronal computation Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e901c6bb1a0b4100a07a29c39d4e8419
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spelling	oai:doaj.org-article:e901c6bb1a0b4100a07a29c39d4e84192021-11-12T14:40:10ZDevelopmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons10.7554/eLife.659542050-084Xe65954https://doaj.org/article/e901c6bb1a0b4100a07a29c39d4e84192021-11-01T00:00:00Zhttps://elifesciences.org/articles/65954https://doaj.org/toc/2050-084XSynaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellular mechanisms underlying the maturation of synaptic integration in interneurons, we combined patch-clamp recordings of excitatory inputs in mouse cerebellar stellate cells (SCs), three-dimensional reconstruction of SC morphology with excitatory synapse location, and biophysical modeling. We found that postnatal maturation of postsynaptic strength was homogeneously reduced along the somatodendritic axis, but dendritic integration was always sublinear. However, dendritic branching increased without changes in synapse density, leading to a substantial gain in distal inputs. Thus, changes in synapse distribution, rather than dendrite cable properties, are the dominant mechanism underlying the maturation of neuronal computation. These mechanisms favor the emergence of a spatially compartmentalized two-stage integration model promoting location-dependent integration within dendritic subunits.Celia BianeFlorian RückerlTherese AbrahamssonCécile Saint-ClomentJean MarianiRyuichi ShigemotoDavid A DiGregorioRachel M SherrardLaurence CathalaeLife Sciences Publications Ltdarticleinterneurondendritic integrationsynaptic transmissiondevelopmentcerebellumneuronal computationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interneuron dendritic integration synaptic transmission development cerebellum neuronal computation Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	interneuron dendritic integration synaptic transmission development cerebellum neuronal computation Medicine R Science Q Biology (General) QH301-705.5 Celia Biane Florian Rückerl Therese Abrahamsson Cécile Saint-Cloment Jean Mariani Ryuichi Shigemoto David A DiGregorio Rachel M Sherrard Laurence Cathala Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
description	Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellular mechanisms underlying the maturation of synaptic integration in interneurons, we combined patch-clamp recordings of excitatory inputs in mouse cerebellar stellate cells (SCs), three-dimensional reconstruction of SC morphology with excitatory synapse location, and biophysical modeling. We found that postnatal maturation of postsynaptic strength was homogeneously reduced along the somatodendritic axis, but dendritic integration was always sublinear. However, dendritic branching increased without changes in synapse density, leading to a substantial gain in distal inputs. Thus, changes in synapse distribution, rather than dendrite cable properties, are the dominant mechanism underlying the maturation of neuronal computation. These mechanisms favor the emergence of a spatially compartmentalized two-stage integration model promoting location-dependent integration within dendritic subunits.
format	article
author	Celia Biane Florian Rückerl Therese Abrahamsson Cécile Saint-Cloment Jean Mariani Ryuichi Shigemoto David A DiGregorio Rachel M Sherrard Laurence Cathala
author_facet	Celia Biane Florian Rückerl Therese Abrahamsson Cécile Saint-Cloment Jean Mariani Ryuichi Shigemoto David A DiGregorio Rachel M Sherrard Laurence Cathala
author_sort	Celia Biane
title	Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
title_short	Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
title_full	Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
title_fullStr	Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
title_full_unstemmed	Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
title_sort	developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/e901c6bb1a0b4100a07a29c39d4e8419
work_keys_str_mv	AT celiabiane developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT florianruckerl developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT thereseabrahamsson developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT cecilesaintcloment developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT jeanmariani developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT ryuichishigemoto developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT davidadigregorio developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT rachelmsherrard developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons AT laurencecathala developmentalemergenceoftwostagenonlinearsynapticintegrationincerebellarinterneurons
_version_	1718430406545506304

Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

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