Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.

<h4>Objective</h4>Neuroimaging evidence suggested that the thalamic nuclei may play different roles in the progress of idiopathic generalized epilepsy (IGE). This study aimed to demonstrate the alterations in morphometry and functional connectivity in the thalamic nuclei in IGE.<h4>...

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Autores principales:	Zhengge Wang, Zhiqiang Zhang, Qing Jiao, Wei Liao, Guanghui Chen, Kangjian Sun, Lianfang Shen, Maoxue Wang, Kai Li, Yijun Liu, Guangming Lu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e903425e8e834401a5f2135111443108
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spelling	oai:doaj.org-article:e903425e8e834401a5f21351114431082021-11-18T07:12:48ZImpairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.1932-620310.1371/journal.pone.0039701https://doaj.org/article/e903425e8e834401a5f21351114431082012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22808050/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Neuroimaging evidence suggested that the thalamic nuclei may play different roles in the progress of idiopathic generalized epilepsy (IGE). This study aimed to demonstrate the alterations in morphometry and functional connectivity in the thalamic nuclei in IGE.<h4>Methods</h4>Fifty-two patients with IGE characterized by generalized tonic-clonic seizures and 67 healthy controls were involved in the study. The three-dimensional high-resolution T1-weighted MRI data were acquired for voxel-based morphometry (VBM) analysis, and resting-state blood-oxygenation level functional MRI data were acquired for functional connectivity analysis. The thalamic nuclei of bilateral medial dorsal nucleus (MDN) and pulvinar, as detected with decreased gray matter volumes in patients with IGE through VBM analysis, were selected as seed regions for functional connectivity analysis.<h4>Results</h4>Different alteration patterns were found in functional connectivity of the thalamic nuclei with decreased gray matter volumes in IGE. Seeding at the MDN, decreased connectivity in the bilateral orbital frontal cortex, caudate nucleus, putamen and amygdala were found in the patients (P<0.05 with correction). However, seeding at the pulvinar, no significant alteration of functional connectivity was found in the patients (P<0.05 with correction).<h4>Conclusions</h4>Some specific impairment of thalamic nuclei in IGE was identified using morphological and functional connectivity MRI approaches. These findings may strongly support the different involvement of the thalamocortical networks in IGE.Zhengge WangZhiqiang ZhangQing JiaoWei LiaoGuanghui ChenKangjian SunLianfang ShenMaoxue WangKai LiYijun LiuGuangming LuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e39701 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhengge Wang Zhiqiang Zhang Qing Jiao Wei Liao Guanghui Chen Kangjian Sun Lianfang Shen Maoxue Wang Kai Li Yijun Liu Guangming Lu Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
description	<h4>Objective</h4>Neuroimaging evidence suggested that the thalamic nuclei may play different roles in the progress of idiopathic generalized epilepsy (IGE). This study aimed to demonstrate the alterations in morphometry and functional connectivity in the thalamic nuclei in IGE.<h4>Methods</h4>Fifty-two patients with IGE characterized by generalized tonic-clonic seizures and 67 healthy controls were involved in the study. The three-dimensional high-resolution T1-weighted MRI data were acquired for voxel-based morphometry (VBM) analysis, and resting-state blood-oxygenation level functional MRI data were acquired for functional connectivity analysis. The thalamic nuclei of bilateral medial dorsal nucleus (MDN) and pulvinar, as detected with decreased gray matter volumes in patients with IGE through VBM analysis, were selected as seed regions for functional connectivity analysis.<h4>Results</h4>Different alteration patterns were found in functional connectivity of the thalamic nuclei with decreased gray matter volumes in IGE. Seeding at the MDN, decreased connectivity in the bilateral orbital frontal cortex, caudate nucleus, putamen and amygdala were found in the patients (P<0.05 with correction). However, seeding at the pulvinar, no significant alteration of functional connectivity was found in the patients (P<0.05 with correction).<h4>Conclusions</h4>Some specific impairment of thalamic nuclei in IGE was identified using morphological and functional connectivity MRI approaches. These findings may strongly support the different involvement of the thalamocortical networks in IGE.
format	article
author	Zhengge Wang Zhiqiang Zhang Qing Jiao Wei Liao Guanghui Chen Kangjian Sun Lianfang Shen Maoxue Wang Kai Li Yijun Liu Guangming Lu
author_facet	Zhengge Wang Zhiqiang Zhang Qing Jiao Wei Liao Guanghui Chen Kangjian Sun Lianfang Shen Maoxue Wang Kai Li Yijun Liu Guangming Lu
author_sort	Zhengge Wang
title	Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
title_short	Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
title_full	Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
title_fullStr	Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
title_full_unstemmed	Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
title_sort	impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity mri.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e903425e8e834401a5f2135111443108
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Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.

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