Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.

Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter...

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Autores principales:	Xuming Chen, Yuanyuan Jiang, Sangcheon Choi, Rolf Pohmann, Klaus Scheffler, David Kleinfeld, Xin Yu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e90b0ffc45fc4710b609327a2014466a
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spelling	oai:doaj.org-article:e90b0ffc45fc4710b609327a2014466a2021-12-02T19:54:36ZAssessment of single-vessel cerebral blood velocity by phase contrast fMRI.1544-91731545-788510.1371/journal.pbio.3000923https://doaj.org/article/e90b0ffc45fc4710b609327a2014466a2021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3000923https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow-related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra-high-field fMRI.Xuming ChenYuanyuan JiangSangcheon ChoiRolf PohmannKlaus SchefflerDavid KleinfeldXin YuPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 9, p e3000923 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xuming Chen Yuanyuan Jiang Sangcheon Choi Rolf Pohmann Klaus Scheffler David Kleinfeld Xin Yu Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
description	Current approaches to high-field functional MRI (fMRI) provide 2 means to map hemodynamics at the level of single vessels in the brain. One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation level-dependent (BOLD) fMRI, while the second is through changes in arteriole diameter, i.e., cerebral blood volume (CBV) fMRI. Here, we introduce cerebral blood flow-related velocity-based fMRI, denoted CBFv-fMRI, which uses high-resolution phase contrast (PC) MRI to form velocity measurements of flow. We use CBFv-fMRI in measure changes in blood velocity in single penetrating microvessels across rat parietal cortex. In contrast to the venule-dominated BOLD and arteriole-dominated CBV fMRI signals, CBFv-fMRI is comparable from both arterioles and venules. A single fMRI platform is used to map changes in blood pO2 (BOLD), volume (CBV), and velocity (CBFv). This combined high-resolution single-vessel fMRI mapping scheme enables vessel-specific hemodynamic mapping in animal models of normal and diseased states and further has translational potential to map vascular dementia in diseased or injured human brains with ultra-high-field fMRI.
format	article
author	Xuming Chen Yuanyuan Jiang Sangcheon Choi Rolf Pohmann Klaus Scheffler David Kleinfeld Xin Yu
author_facet	Xuming Chen Yuanyuan Jiang Sangcheon Choi Rolf Pohmann Klaus Scheffler David Kleinfeld Xin Yu
author_sort	Xuming Chen
title	Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
title_short	Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
title_full	Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
title_fullStr	Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
title_full_unstemmed	Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.
title_sort	assessment of single-vessel cerebral blood velocity by phase contrast fmri.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e90b0ffc45fc4710b609327a2014466a
work_keys_str_mv	AT xumingchen assessmentofsinglevesselcerebralbloodvelocitybyphasecontrastfmri AT yuanyuanjiang assessmentofsinglevesselcerebralbloodvelocitybyphasecontrastfmri AT sangcheonchoi assessmentofsinglevesselcerebralbloodvelocitybyphasecontrastfmri AT rolfpohmann assessmentofsinglevesselcerebralbloodvelocitybyphasecontrastfmri AT klausscheffler assessmentofsinglevesselcerebralbloodvelocitybyphasecontrastfmri AT davidkleinfeld assessmentofsinglevesselcerebralbloodvelocitybyphasecontrastfmri AT xinyu assessmentofsinglevesselcerebralbloodvelocitybyphasecontrastfmri
_version_	1718375935945736192

Assessment of single-vessel cerebral blood velocity by phase contrast fMRI.

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