Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding

During cell division animal cells generate intracellular pressure and round against their environment, but the genes responsible for this are largely unknown. Here the authors use a microcantilever- and RNAi-based assay to screen > 1000 genes and identify 49 genes involved in mitotic cell roundin...

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Autores principales:	Yusuke Toyoda, Cedric J. Cattin, Martin P. Stewart, Ina Poser, Mirko Theis, Teymuras V. Kurzchalia, Frank Buchholz, Anthony A. Hyman, Daniel J. Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e90be210e50b44a588340bc826ea3fc6
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spelling	oai:doaj.org-article:e90be210e50b44a588340bc826ea3fc62021-12-02T17:06:11ZGenome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding10.1038/s41467-017-01147-62041-1723https://doaj.org/article/e90be210e50b44a588340bc826ea3fc62017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01147-6https://doaj.org/toc/2041-1723During cell division animal cells generate intracellular pressure and round against their environment, but the genes responsible for this are largely unknown. Here the authors use a microcantilever- and RNAi-based assay to screen > 1000 genes and identify 49 genes involved in mitotic cell rounding; many are novel to this process.Yusuke ToyodaCedric J. CattinMartin P. StewartIna PoserMirko TheisTeymuras V. KurzchaliaFrank BuchholzAnthony A. HymanDaniel J. MüllerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Toyoda Cedric J. Cattin Martin P. Stewart Ina Poser Mirko Theis Teymuras V. Kurzchalia Frank Buchholz Anthony A. Hyman Daniel J. Müller Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
description	During cell division animal cells generate intracellular pressure and round against their environment, but the genes responsible for this are largely unknown. Here the authors use a microcantilever- and RNAi-based assay to screen > 1000 genes and identify 49 genes involved in mitotic cell rounding; many are novel to this process.
format	article
author	Yusuke Toyoda Cedric J. Cattin Martin P. Stewart Ina Poser Mirko Theis Teymuras V. Kurzchalia Frank Buchholz Anthony A. Hyman Daniel J. Müller
author_facet	Yusuke Toyoda Cedric J. Cattin Martin P. Stewart Ina Poser Mirko Theis Teymuras V. Kurzchalia Frank Buchholz Anthony A. Hyman Daniel J. Müller
author_sort	Yusuke Toyoda
title	Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
title_short	Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
title_full	Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
title_fullStr	Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
title_full_unstemmed	Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
title_sort	genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e90be210e50b44a588340bc826ea3fc6
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Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding

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