Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure

Abstract Heart failure is a major cause of death with an increasing population of elderly individuals. Several studies have demonstrated the involvement of soluble alpha-Klotho (sαKl) in various diseases. However, the correlation between sαKl and heart failure remains to be understood. The aim of th...

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Autores principales:	Manabu Taneike, Makoto Nishida, Kaori Nakanishi, Fusako Sera, Hidetaka Kioka, Ryohei Yamamoto, Tomohito Ohtani, Shungo Hikoso, Toshiki Moriyama, Yasushi Sakata, Keiko Yamauchi-Takihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e90d8e9e631c4da4814eea00182a7c4e
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spelling	oai:doaj.org-article:e90d8e9e631c4da4814eea00182a7c4e2021-12-02T13:50:50ZAlpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure10.1038/s41598-021-81517-92045-2322https://doaj.org/article/e90d8e9e631c4da4814eea00182a7c4e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81517-9https://doaj.org/toc/2045-2322Abstract Heart failure is a major cause of death with an increasing population of elderly individuals. Several studies have demonstrated the involvement of soluble alpha-Klotho (sαKl) in various diseases. However, the correlation between sαKl and heart failure remains to be understood. The aim of this study is to investigate the levels and role of sαKl in patients with heart failure. Twenty-eight consecutive patients with acute heart failure (19 male, 9 female), admitted to the Osaka University Hospital from 2010 to 2018, were enrolled in this study. Mean NYHA score, left ventricular ejection fraction and BNP were 3.3, 17.0% and 588 pg/mL, respectively. SαKl significantly increased in heart failure patients. SαKl on admission were significantly higher in patients with heart failure who showed improvement after intensive treatment than that in patients who did not show improvement after the treatment. SαKl levels decreased significantly in patients who showed improvement. Interestingly, sαKl levels increased in male patients with heart failure, but not in female patients. Our data suggest that soluble αKl may be a novel biomarker for the responsiveness against treatment in patients with heart failure with reduced ejection fraction. Our findings may help developing a personalized therapy for different patients with heart failure.Manabu TaneikeMakoto NishidaKaori NakanishiFusako SeraHidetaka KiokaRyohei YamamotoTomohito OhtaniShungo HikosoToshiki MoriyamaYasushi SakataKeiko Yamauchi-TakiharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manabu Taneike Makoto Nishida Kaori Nakanishi Fusako Sera Hidetaka Kioka Ryohei Yamamoto Tomohito Ohtani Shungo Hikoso Toshiki Moriyama Yasushi Sakata Keiko Yamauchi-Takihara Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure
description	Abstract Heart failure is a major cause of death with an increasing population of elderly individuals. Several studies have demonstrated the involvement of soluble alpha-Klotho (sαKl) in various diseases. However, the correlation between sαKl and heart failure remains to be understood. The aim of this study is to investigate the levels and role of sαKl in patients with heart failure. Twenty-eight consecutive patients with acute heart failure (19 male, 9 female), admitted to the Osaka University Hospital from 2010 to 2018, were enrolled in this study. Mean NYHA score, left ventricular ejection fraction and BNP were 3.3, 17.0% and 588 pg/mL, respectively. SαKl significantly increased in heart failure patients. SαKl on admission were significantly higher in patients with heart failure who showed improvement after intensive treatment than that in patients who did not show improvement after the treatment. SαKl levels decreased significantly in patients who showed improvement. Interestingly, sαKl levels increased in male patients with heart failure, but not in female patients. Our data suggest that soluble αKl may be a novel biomarker for the responsiveness against treatment in patients with heart failure with reduced ejection fraction. Our findings may help developing a personalized therapy for different patients with heart failure.
format	article
author	Manabu Taneike Makoto Nishida Kaori Nakanishi Fusako Sera Hidetaka Kioka Ryohei Yamamoto Tomohito Ohtani Shungo Hikoso Toshiki Moriyama Yasushi Sakata Keiko Yamauchi-Takihara
author_facet	Manabu Taneike Makoto Nishida Kaori Nakanishi Fusako Sera Hidetaka Kioka Ryohei Yamamoto Tomohito Ohtani Shungo Hikoso Toshiki Moriyama Yasushi Sakata Keiko Yamauchi-Takihara
author_sort	Manabu Taneike
title	Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure
title_short	Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure
title_full	Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure
title_fullStr	Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure
title_full_unstemmed	Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure
title_sort	alpha-klotho is a novel predictor of treatment responsiveness in patients with heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e90d8e9e631c4da4814eea00182a7c4e
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Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure

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