Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure

Abstract Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. T...

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Autores principales:	Shun Cao, Taisheng Wang, Jingzhong Yang, Bingliang Hu, Uriel Levy, Weixing Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e90dfa30e2454e7f9421994f3c13a973
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spelling	oai:doaj.org-article:e90dfa30e2454e7f9421994f3c13a9732021-12-02T12:32:45ZNumerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure10.1038/s41598-017-01521-w2045-2322https://doaj.org/article/e90dfa30e2454e7f9421994f3c13a9732017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01521-whttps://doaj.org/toc/2045-2322Abstract Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is determined by the period of the optical interference pattern. However, in traditional WFSIM this period is diffraction limited so that pattern having periodicity smaller than 100 nm cannot be generated and as a result achieving an imaging resolution better than 50 nm is a great challenge. Here, we demonstrate a wide-field optical nanoimaging method based on a meta-sandwich structure (MSS) model. It is found that this structure can support standing wave surface plasmons interference pattern with a period of only 31 nm for 532 nm wavelength incident light. Furthermore, the potential application of the MSS for wide-field super-resolution imaging is discussed and the simulation results show an imaging resolution of sub-20 nm can be achieved. The demonstrated method paves a new route for the improvement of the wide field optical nanoimaging, which can be applied by biological researchers to study biological process conducted in cell membrane, such as mass transportation and others.Shun CaoTaisheng WangJingzhong YangBingliang HuUriel LevyWeixing YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shun Cao Taisheng Wang Jingzhong Yang Bingliang Hu Uriel Levy Weixing Yu Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
description	Abstract Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is determined by the period of the optical interference pattern. However, in traditional WFSIM this period is diffraction limited so that pattern having periodicity smaller than 100 nm cannot be generated and as a result achieving an imaging resolution better than 50 nm is a great challenge. Here, we demonstrate a wide-field optical nanoimaging method based on a meta-sandwich structure (MSS) model. It is found that this structure can support standing wave surface plasmons interference pattern with a period of only 31 nm for 532 nm wavelength incident light. Furthermore, the potential application of the MSS for wide-field super-resolution imaging is discussed and the simulation results show an imaging resolution of sub-20 nm can be achieved. The demonstrated method paves a new route for the improvement of the wide field optical nanoimaging, which can be applied by biological researchers to study biological process conducted in cell membrane, such as mass transportation and others.
format	article
author	Shun Cao Taisheng Wang Jingzhong Yang Bingliang Hu Uriel Levy Weixing Yu
author_facet	Shun Cao Taisheng Wang Jingzhong Yang Bingliang Hu Uriel Levy Weixing Yu
author_sort	Shun Cao
title	Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_short	Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_full	Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_fullStr	Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_full_unstemmed	Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_sort	numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e90dfa30e2454e7f9421994f3c13a973
work_keys_str_mv	AT shuncao numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure AT taishengwang numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure AT jingzhongyang numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure AT binglianghu numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure AT uriellevy numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure AT weixingyu numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure
_version_	1718394013287972864

Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure

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