Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure

Abstract Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. T...

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Autores principales: Shun Cao, Taisheng Wang, Jingzhong Yang, Bingliang Hu, Uriel Levy, Weixing Yu
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e90dfa30e2454e7f9421994f3c13a973
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spelling oai:doaj.org-article:e90dfa30e2454e7f9421994f3c13a9732021-12-02T12:32:45ZNumerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure10.1038/s41598-017-01521-w2045-2322https://doaj.org/article/e90dfa30e2454e7f9421994f3c13a9732017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01521-whttps://doaj.org/toc/2045-2322Abstract Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is determined by the period of the optical interference pattern. However, in traditional WFSIM this period is diffraction limited so that pattern having periodicity smaller than 100 nm cannot be generated and as a result achieving an imaging resolution better than 50 nm is a great challenge. Here, we demonstrate a wide-field optical nanoimaging method based on a meta-sandwich structure (MSS) model. It is found that this structure can support standing wave surface plasmons interference pattern with a period of only 31 nm for 532 nm wavelength incident light. Furthermore, the potential application of the MSS for wide-field super-resolution imaging is discussed and the simulation results show an imaging resolution of sub-20 nm can be achieved. The demonstrated method paves a new route for the improvement of the wide field optical nanoimaging, which can be applied by biological researchers to study biological process conducted in cell membrane, such as mass transportation and others.Shun CaoTaisheng WangJingzhong YangBingliang HuUriel LevyWeixing YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shun Cao
Taisheng Wang
Jingzhong Yang
Bingliang Hu
Uriel Levy
Weixing Yu
Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
description Abstract Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is determined by the period of the optical interference pattern. However, in traditional WFSIM this period is diffraction limited so that pattern having periodicity smaller than 100 nm cannot be generated and as a result achieving an imaging resolution better than 50 nm is a great challenge. Here, we demonstrate a wide-field optical nanoimaging method based on a meta-sandwich structure (MSS) model. It is found that this structure can support standing wave surface plasmons interference pattern with a period of only 31 nm for 532 nm wavelength incident light. Furthermore, the potential application of the MSS for wide-field super-resolution imaging is discussed and the simulation results show an imaging resolution of sub-20 nm can be achieved. The demonstrated method paves a new route for the improvement of the wide field optical nanoimaging, which can be applied by biological researchers to study biological process conducted in cell membrane, such as mass transportation and others.
format article
author Shun Cao
Taisheng Wang
Jingzhong Yang
Bingliang Hu
Uriel Levy
Weixing Yu
author_facet Shun Cao
Taisheng Wang
Jingzhong Yang
Bingliang Hu
Uriel Levy
Weixing Yu
author_sort Shun Cao
title Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_short Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_full Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_fullStr Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_full_unstemmed Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
title_sort numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/e90dfa30e2454e7f9421994f3c13a973
work_keys_str_mv AT shuncao numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure
AT taishengwang numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure
AT jingzhongyang numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure
AT binglianghu numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure
AT uriellevy numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure
AT weixingyu numericalanalysisofwidefieldopticalimagingwithasub20nmresolutionbasedonametasandwichstructure
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